维生素D血清水平和受体遗传多态性与乙型肝炎病毒和HIV感染

StephenW

Biomark Med. 2017 Sep;11(9):733-740. doi: 10.2217/bmm-2017-0022. Epub  2017 Sep 15.
Vitamin D serum levels and receptor genetic polymorphisms are associated with hepatitis B virus and HIV infections and IFN-λ levels.Gao W1, Wang R2, Wang X3, Wu H2, Wang Y1, Lu X2, Li L2, Zheng J1, Li W1.
Author information
1Center of Interventional Oncology & Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.2Center of Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.3Department of Oncology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.

AbstractAIM: Vitamin D is involved in antiviral/antitumor activities. Its associations to hepatitis B virus (HBV), HIV and hepatocellular carcinoma (HCC) are unclear.
MATERIALS & METHODS: A retrospective study was conducted on 232 chronic hepatitis B (CHB) patients and 72 HIV-infected patients. The correlation between serum 25(OH)D3 and 25 vitamin D receptor single nucleotide polymorphisms to disease progression and interferons were evaluated.
RESULTS: The 25(OH)D3 was associated with HBV infection and progression. In HIV, it was linked to treatment responsiveness. In CHB, cirrhotic and HCC patients, it was associated with viral load. Fourteen single nucleotide polymorphisms were related to disease progression in HBV infection. In HCC, IFN-λ levels were associated with 25(OH)D3 levels negatively.
CONCLUSION: Serum vitamin D level and vitamin D receptor genetic polymorphisms are associated with CHB and HIV disease progression and IFN-λs.


KEYWORDS: HIV; disease progression; genetic polymorphism; hepatocellular carcinoma; interferons; viral hepatitis B; viral infection; vitamin D

PMID:29493287DOI:10.2217/bmm-2017-0022

StephenW

Biomark Med。 2017年9月; 11（9）：733-740。 doi：10.2217 / bmm-2017-0022。电子书2017年9月15日。
维生素D血清水平和受体遗传多态性与乙型肝炎病毒和HIV感染以及IFN-λ水平有关。
Gao W1，Wang R2，Wang X3，Wu H2，Wang Y1，Lu X2，Li L2，Zheng J1，Li W1。
作者信息

1
    首都医科大学附属北京佑安医院介入肿瘤及肝病研究中心，北京100069
2
    首都医科大学附属北京佑安医院感染科中心，北京100069
3
    首都医科大学附属北京佑安医院肿瘤科，北京100069

抽象
目标：

维生素D参与抗病毒/抗肿瘤活性。它与乙型肝炎病毒（HBV），HIV和肝细胞癌（HCC）的关联尚不清楚。
材料与方法：

对232例慢性乙型肝炎（CHB）患者和72例HIV感染患者进行了回顾性研究。血清25（OH）D3和25维生素D受体单核苷酸多态性与疾病进展和干扰素之间的相关性进行了评估。
结果：

25（OH）D3与HBV感染和进展有关。在艾滋病毒中，它与治疗反应有关。在CHB，肝硬化和HCC患者中，它与病毒载量有关。 14个单核苷酸多态性与HBV感染的疾病进展有关。在HCC中，IFN-λ水平与25（OH）D3水平呈负相关。
结论：

血清维生素D水平和维生素D受体基因多态性与CHB和HIV疾病进展以及IFN-λs相关。
关键词：

HIV;疾病进展;遗传多态性;肝细胞癌;干扰素;病毒性乙型肝炎;病毒感染;维生素D

结论：
    29493287
DOI：
    10.2217 / BMM-2017-0022