Biomark Med. 2017 Sep;11(9):733-740. doi: 10.2217/bmm-2017-0022. Epub 2017 Sep 15.
Vitamin D serum levels and receptor genetic polymorphisms are associated with hepatitis B virus and HIV infections and IFN-λ levels.Gao W1, Wang R2, Wang X3, Wu H2, Wang Y1, Lu X2, Li L2, Zheng J1, Li W1. Author information 1Center of Interventional Oncology & Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.2Center of Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.3Department of Oncology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
AbstractAIM: Vitamin D is involved in antiviral/antitumor activities. Its associations to hepatitis B virus (HBV), HIV and hepatocellular carcinoma (HCC) are unclear.
MATERIALS & METHODS: A retrospective study was conducted on 232 chronic hepatitis B (CHB) patients and 72 HIV-infected patients. The correlation between serum 25(OH)D3 and 25 vitamin D receptor single nucleotide polymorphisms to disease progression and interferons were evaluated.
RESULTS: The 25(OH)D3 was associated with HBV infection and progression. In HIV, it was linked to treatment responsiveness. In CHB, cirrhotic and HCC patients, it was associated with viral load. Fourteen single nucleotide polymorphisms were related to disease progression in HBV infection. In HCC, IFN-λ levels were associated with 25(OH)D3 levels negatively.
CONCLUSION: Serum vitamin D level and vitamin D receptor genetic polymorphisms are associated with CHB and HIV disease progression and IFN-λs.