CD4 + CD25 +调节性T细胞对慢性乙型肝炎患者树突状细胞的免疫

StephenW

J Viral Hepat. 2018 Jan 18. doi: 10.1111/jvh.12863. [Epub ahead of print]
The immunosuppressive effects of CD4+ CD25+ regulatory T cells on dendritic cells in patients with chronic hepatitis B.
Zhou PP1, Xu J1,2, Dai MJ1, Shi YY1, Wu GP1, Fang Y1, Yan XB1.
Author information

1
    Department of Infectious Diseases, the First Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
2
    Shengli Oilfield Central Hospital, Dongying, Shandong province, China.

Abstract

The characteristics and functions of CD4+ CD25+ regulatory T cells (Tregs) have been well defined in murine and human systems. However, the interaction or cross-talk between CD4+ CD25+ Tregs and dendritic cells (DCs) remains controversial. In this study, the effects of chronic hepatitis B (CHB) CD4+ CD25+ Tregs on the maturation and function of monocyte-derived DCs were examined. The results showed that CD4+ CD25+ render the DCs inefficient as antigen-presenting cells (APCs) despite prestimulation with CD40 ligand. This effect was marginally reverted by applying neutralizing antibodies (Abs) to IL-10 and TGF-β. There was an increased IL-10 and TGF-βsecretion and reduced expression of costimulatory molecules in DC. Thus, in addition to a direct suppressor effect on CD4+ T cells, CD4+ CD25+ may modulate the immune response through DCs in CHB patients. This article is protected by copyright. All rights reserved.
KEYWORDS:

CD4+CD25+ regulatory T cells (Tregs); chronic hepatitis B (CHB); dendritic cells (DCs); immune cross-talk

PMID:
    29345851
DOI:
    10.1111/jvh.12863

StephenW

J病毒肝脏。 2018年1月18日。doi：10.1111 / jvh.12863。 [电子版提前打印]
CD4 + CD25 +调节性T细胞对慢性乙型肝炎患者树突状细胞的免疫抑制作用
周PP1，徐1 1,2，戴敏杰1，石Y 1 1，吴GP 1，方1 1，颜晓斌1。
作者信息

1
    徐州医学院附属第一医院感染科，徐州221002
2
    中国山东省东营市胜利油田中心医院

抽象

CD4 + CD25 +调节性T细胞（Tregs）的特征和功能已经在小鼠和人系统中得到很好的定义。然而，CD4 + CD25 + Tregs与树突状细胞（DCs）之间的相互作用或相互关系仍然存在争议。在这项研究中，慢性乙型肝炎（CHB）CD4 + CD25 +调节性T细胞对成熟和功能的单核细胞来源的DC进行了审查。结果显示，CD4 + CD25 +使得DCs作为抗原呈递细胞（APCs）低效，尽管用CD40配体预刺激。通过对IL-10和TGF-β应用中和抗体（Abs），这一效应稍微恢复。 DC中IL-10和TGF-β分泌增加，共刺激分子表达减少。因此，除了对CD4 + T细胞的直接抑制作用之外，CD4 + CD25 +可能通过DC调节CHB患者的免疫应答。本文受版权保护。版权所有。
关键词：

CD4 + CD25 +调节性T细胞（Tregs）;慢性乙型肝炎（CHB）;树突状细胞（DC）;免疫交谈

结论：
    29345851
DOI：
    10.1111 / jvh.12863

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