J Viral Hepat. 2018 Jan 18. doi: 10.1111/jvh.12863. [Epub ahead of print]
The immunosuppressive effects of CD4+ CD25+ regulatory T cells on dendritic cells in patients with chronic hepatitis B.
Zhou PP1, Xu J1,2, Dai MJ1, Shi YY1, Wu GP1, Fang Y1, Yan XB1.
Author information
1
Department of Infectious Diseases, the First Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
2
Shengli Oilfield Central Hospital, Dongying, Shandong province, China.
Abstract
The characteristics and functions of CD4+ CD25+ regulatory T cells (Tregs) have been well defined in murine and human systems. However, the interaction or cross-talk between CD4+ CD25+ Tregs and dendritic cells (DCs) remains controversial. In this study, the effects of chronic hepatitis B (CHB) CD4+ CD25+ Tregs on the maturation and function of monocyte-derived DCs were examined. The results showed that CD4+ CD25+ render the DCs inefficient as antigen-presenting cells (APCs) despite prestimulation with CD40 ligand. This effect was marginally reverted by applying neutralizing antibodies (Abs) to IL-10 and TGF-β. There was an increased IL-10 and TGF-βsecretion and reduced expression of costimulatory molecules in DC. Thus, in addition to a direct suppressor effect on CD4+ T cells, CD4+ CD25+ may modulate the immune response through DCs in CHB patients. This article is protected by copyright. All rights reserved.
KEYWORDS:
CD4+CD25+ regulatory T cells (Tregs); chronic hepatitis B (CHB); dendritic cells (DCs); immune cross-talk