恩替v其他HBV核苷（酸）类似物长期治疗期间对HBV相关和其他

StephenW

Prospective, Randomized Assessment of HBV-associated and Other Clinical Outcome Events During Long-Term Therapy With Entecavir or Other HBV Nucleos(t)ide Analogues in Patients With Chronic HBV Infection                                     Reported by Jules Levin AASLD Annual Meeting 2017, Washington, DC, USA, October 20-24 J-L Hou,1W Zhao,2C-H Lee,3H-W Hann,4C-Y Peng,5T Tanwandee,6V Morozov,7CP Berg,8JD Sollano,9A Streinu-Cercel,10H Cheinquer,11A Thiry,12EL Cooney,13S-G Lim141Nanfang Hospital, Guangzhou, China; 22nd Hospital Nanjing, Nanjing, China; 3Daegu Catholic University Hospital, Daegu, Republic of Korea; 4Thomas Jefferson University Hospital, Philadelphia, PA; 5China Medical University Hospital, Taichung, Taiwan; 6Faculty of Medicine SirirajHospital, Bangkok, Thailand; 7LLC Medical Company " Hepatolog", Samara, Russian Federation; 8Universitaetsklinikum Tuebingen, Tuebingen, Germany; 9Cardinal Santos Medical Center, Manila, Philippines; 10Carol Davila University of Medicine and Pharmacy, National Institute for Infectious Diseases "Prof.Dr. MateiBals", Bucharest, Romania; 11Hospital de Clinicasde Porto Alegre, Porto Alegre, Brazil; 12Bristol-Myers Squibb Inc., Princeton, NJ; 13Bristol-Myers Squibb Inc., Wallingford, CT; 14National University Health System, National University of Singapore, Singapore.

                                                                       

hbv30year

StephenW, glad to know u still working hard here.
so this report tells us ETV is nothing special. but in china it is more expensive than lamivudine

StephenW

回复 hbv30year 的帖子

Ditto, good to hear from you again. I hope you are well and prosperous too!

I cannot say that I disagree with your observation that ETV is "nothing special", but if you look at the data, in the ETV group, there is less therapy crossover (5.6% versus 12.2%), and takes longer (medium 88 months) time before change if change is needed. That means ETV is a more stable treatment option.
As for price comparison between ETV and Lam, I think Lam is a first generation drug whereas ETV can be considered third generation. Like your old pickup truck, it gets you from A to B just the same as a newer more expensive one.

You take care.
Best,
Stephen

小牡丹

In Todays China ET is cheaper than LM on Internet .Are not you two Chinese ?

StephenW

回复 小牡丹 的帖子

I am Chinese, living in Sydney, Australia. HBV30, he wanders a lot, drives a pickup truck somewhere, and has nine lives.

neilhbver

I admire you two.  Thank you for giving useful articles!

hbv30year

回复 StephenW 的帖子

, right, didn't notice that. is crossover=mutation?

StephenW

回复 hbv30year 的帖子

Maybe also side-effects.