适度的咖啡摄入量降低了肝癌，肝硬化，纤维化的风险

StephenW

Moderate coffee intake reduces risk for liver cancer, cirrhosis, fibrosis
November 16, 2017

In a roundtable format, experts gathered to discuss the latest research on coffee and liver disease, which indicate that drinking approximately three to five cups per day is associated with a reduced risk for hepatocellular carcinoma, cirrhosis and fibrosis.
Graeme Alexander, MD
Graeme Alexander

“I’ve been in the field for 30-odd years and it’s not a topic that’s come up until very recently. I would imagine patients will always ask, ‘What can I do, to help myself?’ And the advice is always lose weight, don’t drink too much alcohol and don’t smoke at all — a lot of advice that is somewhat negative,” Graeme Alexander, MD, senior advisor to the British Liver Trust, told Healio.com/Hepatology. “But to be told something positive, rather than negative, is a good message. If people ask, ‘Should I drink coffee?’ the answer would be yes.”


During the roundtable discussion, hosted by the Institute for Scientific Information on Coffee in association with the British Liver Trust, attendees highlighted data on coffee consumption and liver cancer.

Data from the International Agency for Research on Cancer showed no correlation between coffee intake and any forms of cancer, whereas the agency suggested that coffee consumption may reduce the risk for certain cancers.

Additionally, the attendees discussed study results from Finland, Japan, Europe and the U.S. that showed inverse associations between coffee consumption and activity of the gamma-glutamyl transferase liver enzyme. Members of the roundtable noted that these findings were valuable because the effect appears in genetically different populations.

Data from Italy and the U.S. showed correlation between coffee consumption and a 25% to 75% reduced risk for cirrhosis. In the Italian study, this association remained regardless of a patient’s history of hepatitis B and hepatitis C.

While the precise mechanisms remain unclear, Alexander suggested that any of the components found in coffee, including coffee oils, kahweol and cafestol and antioxidants, may explain the effect of coffee consumption on liver health.

“It doesn’t appear to be the caffeine, it does appear to be other contents, which are found in other drinks such as [certain kinds of] tea,” Alexander said.

Of interest to the roundtable members, a study from Finland showed that coffee intake was inversely associated with liver cancer, regardless of whether it was boiled or filtered.

The roundtable members suggested that patient-to-patient advice is often rated highly and potentially more likely to affect individuals’ opinions compared with advice from a health professional. They also advise that understanding liver disease risk factors can influence a patient’s interest in diet and lifestyle changes.

“When I started looking up how coffee might be working on fibrosis and liver cancer, I found a lot of data ... that showed coffee appeared to halt or partly reverse the effects of aging, so I began to become more interested,” Alexander said. “If coffee has an effect on cellular senescence, that would be fascinating, because we’re desperate to try and find drugs that inhibit the process or reverse the process of liver injury.” – by Talitha Bennett

Disclosure: Healio.com/Hepatology was unable to determine relevant financial disclosures of the other researchers at the time of publication.

StephenW

适度的咖啡摄入量降低了肝癌，肝硬化，纤维化的风险
2017年11月16日

在圆桌会议上，专家聚集一堂讨论咖啡和肝脏疾病的最新研究，这些研究表明每天饮用三到五杯咖啡与降低肝细胞癌，肝硬化和纤维化的风险有关。
Graeme Alexander，MD
格雷姆亚历山大

“我已经在这个领域工作了30多年了，这不是一个直到最近才出现的话题，我可以想象，病人总是会问：'我该怎么做，帮助自己？而且建议总是减肥，不要喝太多的酒，根本不吸烟，很多的建议是有些负面的，“英国肝脏信托基金会高级顾问格雷姆·亚历山大博士告诉Healio.com。 “但是被告知积极而不是消极是一个好消息，如果有人问：”我应该喝咖啡吗？答案是肯定的。“
也可以看看

咖啡延迟肝脏疾病进展，延长生存后...
咖啡消费与降低慢性病风险相关
频繁的咖啡，凉茶的摄入量与较低水平的肝脏有关。

在与英国肝脏信托协会联合举办的咖啡科学信息研究所举办的圆桌讨论中，与会者强调了有关咖啡消费和肝癌的数据。

来自国际癌症研究机构的数据显示咖啡摄入量与任何形式的癌症之间没有相关性，该机构认为咖啡可能会降低某些癌症的风险。

此外，与会者讨论了来自芬兰，日本，欧洲和美国的研究结果，显示了咖啡消耗与γ-谷氨酰转移酶肝酶活性之间的对应关系。圆桌会议成员指出，这些发现是有价值的，因为这种效应出现在基因不同的人群中。

来自意大利和美国的数据显示，咖啡消费与肝硬化风险降低25％至75％之间存在相关性。在意大利的研究中，无论患者有乙型肝炎和丙型肝炎的病史，这种联系都是有史以来的。

虽然确切的机制尚不清楚，亚历山大建议，在咖啡中发现的任何成分，包括咖啡油，咖啡和cafestol和抗氧化剂，可以解释咖啡消费对肝脏健康的影响。

亚历山大说：“它似乎不是咖啡因，它似乎是其他内容，在其他饮料，如[某些茶]中发现的。

对圆桌会员感兴趣的是芬兰的一项研究表明，咖啡摄入量与肝癌呈负相关，无论是煮沸还是过滤。

圆桌会员建议，患者对患者的建议通常被评为高度的，并且与健康专家的建议相比，可能更可能影响个人的意见。他们还建议了解肝脏疾病风险因素可以影响患者对饮食和生活方式改变的兴趣。

“当我开始研究如何咖啡可能在纤维化和肝癌的工作，我发现了很多数据...显示咖啡是暂停或部分扭转衰老的影响，所以我开始变得更有兴趣说，会令人着迷，因为我们急于尝试寻找抑制过程或逆转肝损伤过程的药物。“ - Talitha Bennett

披露：Healio.com/Hepatology在发布时无法确定其他研究人员的相关财务披露。

StephenW

Coffee consumption associated with reduced risk for chronic liver disease

Recent study data revealed an association between coffee consumption and a reduced risk for developing chronic liver disease, particularly in non-alcoholic fatty liver disease, alcoholic liver disease and chronic hepatitis C. Read more

Frequent coffee, herbal tea intake linked to lower levels of liver stiffness

Researchers observed an association between more frequent coffee and herbal tea consumption and lower liver stiffness measurements, according to a recently published study. Read more

Drinking coffee reduces risk for death

Among people of various ethnicities and cultures, higher coffee consumption — whether caffeinated or decaffeinated — was associated with all-cause and cause-specific mortality benefits, according to two new studies published in Annals of Internal Medicine. Read more

Coffee protects against, genetics increase risk for alcoholic hepatitis in drinkers

Heavy alcohol drinkers presenting with the PNPLA3 G/G genotype who do not drink coffee on a regular basis have the greatest risk for alcoholic hepatitis, according to data presented during a plenary session at ACG 2016. Read more

Coffee delays liver disease progression, extends survival post-LT

Drinking at least 200 mL coffee a day may stave off the advancement of alcoholic liver disease and some cases of primary sclerosing cholangitis in patients with end-stage liver disease awaiting liver transplant, according to recent published findings. In addition, coffee consumption may increase survival post-transplant. Read more

Daily coffee consumption may reduce risk for cirrhosis

In a systematic review and meta-analysis, researchers in the UK found that increased coffee consumption reduced the risk for cirrhosis, according to published findings in Alimentary Pharmacology and Therapeutics.

Perspective
Naga P. Chalasani, MD

Naga P. Chalasani

There is growing agreement among the experts that coffee drinking offers protection against chronic liver disease, cirrhosis and liver cancer. However, it is not clear cut how much coffee one would have to drink each day to derive such benefits and, furthermore, it is not clear if benefit is limited to certain type of caffeinated beverages or certain subpopulations (eg, obese, diabetic, men).

Logical next steps would be to undertake basic experiments to elucidate which ingredients contained within caffeinated beverages are responsible for such benefits, such that those ingredients can be developed as therapeutic targets. Also, in one preliminary study there was an interesting interaction between PNPLA3 genetic variation and coffee drinking for causing acute alcoholic hepatitis among heavy consumers of alcohol and this preliminary observation needs to expand to other types of chronic liver disease.

    Naga P. Chalasani, MD
    David W. Crabb Professor of Medicine
    Associate Dean for Clinical Research
    Director, Division of Gastroenterology and Hepatology
    Indiana University School of Medicine

Disclosures: Chalasani reports no relevant financial disclosures.

StephenW

与慢性肝病风险降低相关的咖啡消耗
也可以看看

    咖啡延迟肝脏疾病进展，延长生存后...
    咖啡消费与降低慢性病风险相关
    频繁的咖啡，凉茶的摄入量与较低水平的肝脏有关。

最近的研究数据显示，咖啡消费与发展为慢性肝病的风险降低有关，尤其是非酒精性脂肪肝，酒精性肝病和慢性丙型肝炎。阅读更多

频繁的咖啡，凉茶摄入量与肝脏僵硬程度较低有关

根据最近发表的一项研究，研究人员观察到更频繁的咖啡和凉茶消费之间的联系，以及更低的肝脏硬度测量。阅读更多

喝咖啡可以降低死亡风险

根据“内科医学年鉴”（Annals of Internal Medicine）发表的两项新研究，在不同种族和文化的人群中，不论是含咖啡因还是不含咖啡因的咖啡摄入量都高于全因和特定死亡率。阅读更多

咖啡防止，遗传学增加饮酒者酒精性肝炎的风险

根据ACG 2016全体会议期间提供的数据，呈现PNPLA3 G / G基因型的重度饮酒者不定期喝咖啡的风险是酒精性肝炎的最大风险。

咖啡延迟肝脏疾病进展，延长LT后的生存

根据最近发表的研究结果，每天至少喝200毫升咖啡可能会阻止酒精性肝病的发展，以及一些终末期肝病等待肝移植的原发性硬化性胆管炎病例。此外，咖啡的消费可能会增加移植后的生存。阅读更多

每日喝咖啡可能会降低肝硬化的风险

在一项系统性综述和荟萃分析中，英国研究人员发现，咖啡消费量的增加降低了肝硬化的风险，根据发表在“消化药理学和治疗学”上的发现。阅读更多

    1
    2

透视
Naga P. Chalasani，MD

纳卡P. Chalasani

专家们越来越认同，喝咖啡可以防止慢性肝病，肝硬化和肝癌。然而，不清楚每天要喝多少咖啡来获得这样的益处，而且还不清楚是否有益于某些类型的含咖啡因的饮料或某些亚群（如肥胖，糖尿病，男性）。

逻辑的下一步将是进行基本的实验来阐明含咖啡因的饮料中所含的哪些成分对这些益处负有责任，使得这些成分可以作为治疗靶标开发。此外，在一项初步研究中，PNPLA3基因变异与喝咖啡引起急性酒精性肝炎之间存在着令人感兴趣的相互作用，这种初步观察需要扩展到其他类型的慢性肝病。

    Naga P. Chalasani，MD
    David W. Crabb医学教授
    临床研究副院长
    胃肠病与肝病学部主任
    印第安纳大学医学院

披露：Chalasani报告没有相关的财务披露。

Hepbest

看来我要改变一下不喜欢喝咖啡的习惯啦  ：D

不宜人群
患高血压、冠心病、动脉硬化等疾病——长期或大量饮用咖啡，可引起心血管疾病。
老年妇女——咖啡会减少钙质、引起骨质疏松。妇女绝经后，每天需要加十倍的钙量。
胃病患者——喝咖啡过量可引起胃病恶化。
孕妇——饮过量咖啡，可导致胎儿畸形或流产。
维生素B1缺乏者——维生素B1可保持神经系统的平衡和稳定，而咖啡对其有破坏作用。
癌症患者——摄取过量的咖啡因对正常人有致癌的危险。

tacolynn

与会者讨论了来自芬兰，日本，欧洲和美国的研究结果，显示了咖啡消耗与γ-谷氨酰转移酶肝酶活性之间的对应关系。（我老公的亲身体验支持这个研究结果）

2015年5月15日，发病检查，γ-谷氨酰转移酶肝酶高达90.5
2015年6月19日，78.1
2015年7月17日，71.5
2015年8月14日，60.2
2015年9月11日，64.2
2015年10月7日，66
2015年11月4日，65
2016年1月10日，60
2016年3月4日，62.4（这个月底的时候买了咖啡机，开始每天喝两杯现磨咖啡，之前都是每天一袋速溶咖啡）
2016年4月3日，48.3
2016年8月5日，46.6
2017年2月23日，34.7
2017年8月19日，29.5

newchinabok

回复 tacolynn 的帖子

我试过，长期喝coffee，你的胃就废了

tacolynn

回复 newchinabok 的帖子

那是你个人的原因吧，胃不好的就别空腹喝。反正我们长期早餐的时候喝咖啡，胃没毛病。

newchinabok

回复 tacolynn 的帖子

也许是我的原因，早餐油条加咖啡，中西混搭。哈哈

antiHBVren

回复 tacolynn 的帖子

哈哈，这个效果就赶上药物啦