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Compounds in Development for Chronic Hepatitis B
Updated February 2017
FAMILY/DRUG NAME
MECHANISM
COMPANY
WEBSITE
USA STATUS
Interferons: Mimic infection-fighting immune substances naturally produced in the body.
Intron A (Interferon alfa-2b)
Immunomodulator
Merck, USA
merck.com
Approved 1991
Pegasys (Peginterferon alfa-2a)
Immunomodulator
Genentech, USA
gene.com
Approved 2005
Nucleos(t)ide Analogues: Interfere with viral DNA polymerase used for HBV replication
Epivir (Lamivudine)
Inhibits viral DNA polymerase
GlaxoSmithKline (GSK)
gsk.com
Approved 1998
Hepsera (Adefovir dipivoxil)
Inhibits viral DNA polymerase
Gilead Sciences, USA
gilead.com
Approved 2002
Baraclude (Entecavir)
Inhibits viral DNA polymerase
Bristol-Myers Squibb, USA
bms.com
Approved 2005
Tyzeka (Telbivudine)
Inhibits viral DNA polymerase
Novartis, USA
novartis.com
Approved 2006
Viread (Tenofovir)
Inhibits viral DNA polymerase
Gilead Sciences
gilead.com
Approved 2008
Vemlidy (Tenofovir alafenamide/TAF)
Prodrug of tenofovir
Gilead Sciences
gilead.com
Approved Nov. 2016
Levovir (Clevudine)
Inhibits viral DNA polymerase
Bukwang, S. Korea
bukwang.co.kr
Approved 2006 in S. Korea
Zadaxin
Immunomodulator
SciClone, USA
sciclone.com
Approved outside USA
DIRECT ACTING ANTIVIRALS: Targets the virus and interferes in the HBV replication process
TDF Pro Drugs: A modified tenofovir drug that can get into liver cells more easily
TXL (CMX 157)
Prodrug of tenofovir
ContraVir, USA
contravir.com
Phase II
Silencing RNA’s (siRNAs): Interferes and destroys viral RNA
ARB-1467
RNAi gene silencer (1.0)
Arbutus Biopharma, Canada
arbutusbio.com
Phase II
ALN-HBV
RNAi gene silencer
Alnylam, USA
alnylam.com
Preclinical
Hepbarna (BB-HB-331)
RNAi gene silencer
Benitec, Australia
benitec.com
Preclinical
ARB-1740
RNAi gene silencer (2.0)
Arbutus Biopharma
arbutusbio.com
Preclinical
Lunar-HBV
RNAi gene silencer
Arcturus, USA with Janssen of J&J
arcturusrx.com
Preclinical
Entry Inhibitors: Interferes with HBV getting into liver cells
Myrcludex B
Entry inhibitor
Hepatera, Russia with MYR GmbH, Germany
myr-pharma.com
Phase II
Capsid Inhibitors: Interferes with the viral DNA protein shield
Morphothiadin (GLS4)
Capsid inhibitor
HEC Pharma,
PR China
pharm.hec.cn/en
Phase II
NVR 3-778
Capsid inhibitor
Janssen of J&J
janssen.com
Phase II
AIC 649
Capsid inhibitor
AiCuris, Germany
aicuris.com
Phase I
JNJ56136379
Capsid Inhibitor
Janssen of J&J
janssen.com
Phase I
ABI-H0731
Capsid inhibitor
Assembly Biosciences, USA
assemblybio.com
Phase I
AB-423
Capsid inhibitor
Arbutus Biopharma
arbutusbio.com
Preclinical
HBsAg Inhibitors: Interferes with production of HBV surface antigen (sAg)
Rep 2139
sAg inhibitor
REPLICor, Canada
replicor.com
Phase II
Rep 2165
sAg inhibitor
REPLICor
replicor.com
Phase II
RO7020322 (RG7834)
sAg inhibitor
Roche
roche.com
Phase I
Antisense Molecules: Binds to the viral mRNA to prevent it from turning into viral protein
IONIS-HBVRx (GSK3228836)
Viral protein inhibitor
Ionis Pharma, USA with GSK
ionispharma.com
Phase I
IONIS-HBVLRx (GSK33389404)
Viral protein inhibitor
Ionis Pharma with GSK
ionispharma.com
Phase I
INDIRECT ACTING ANTIVIRALS: Targets the human immune system to attack the HBV virus
Therapeutic Vaccines: Vaccine technology used to stimulate the immune system as a treatment
GS 4774
Therapeutic vaccine
Gilead with GlobeImmune, USA
gilead.com
Phase II
INO-1800
Therapeutic vaccine
Inovio, USA
inovio.com
Phase I
HB-110
Therapeutic vaccine
Ichor, USA with Janssen
ichorms.com
Phase I
TG1050
Therapeutic vaccine
Transgene, France
transgene.com
Phase I
HepTcell
Therapeutic vaccine
Altimmune, USA
altimmune.com
Phase I
TomegaVax HBV
Therapeutic vaccine
TomegaVax, USA
tomegavax.com
Preclinical
Innate Immune Defense Pathway: Compounds that activate the innate immune system
GS 9620
TLR-7 agonist
Gilead Sciences
gilead.com
Phase II
RO6864018 (RG7795, ANA773)
TLR-7 agonist
Roche
roche.com
Phase II
SB9200
RIG -1 and NOD2 agonist
Spring Bank Pharmaceuticals, USA
springbankpharm.com
Phase II
Host Acting Pathway: Compounds that induce programmed cell death (apoptosis)
EYP001
FXR agonist
Enyo Pharma, France
enyopharma.com
Phase I
CRV 431 (CPI 431-32)
Ciclofillin inhibitor
ContraVir
contravir.com
Preclinical
HEPATITIS DELTA VIRUS (HDV)
Myrcludex B
Entry inhibitor
MYR-GmbH
myr-pharma.com
Phase II
Lonafarnib
Prenylation inhibitor
Eiger Biopharma, USA
eigerbio.com
Phase II
Pegylated Interferon Lambda
Immunomodulator
Eiger Biopharma, USA
eigerbio.com
Phase II
Rep 2139
HBsAg inhibitor
REPLICor
replicor.com
Phase II
ALN-HDV
RNAi gene silencer
Alnylam
alnylam.com
Preclinical
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发表于 2017-3-1 19:27
