肝胆相照论坛

标题: 新药展望 [打印本页]

作者: yelanglms    时间: 2017-3-1 19:27     标题: 新药展望

http://www.hepb.org/treatment-and-management/drug-watch/

大家看这个网址,有新药展望!

作者: 齐欢畅2    时间: 2017-3-1 22:23

Compounds in Development for Chronic Hepatitis B

Updated February 2017



FAMILY/DRUG NAME





MECHANISM



COMPANY



WEBSITE


USA STATUS

Interferons: Mimic infection-fighting immune substances naturally produced in the body.

Intron A (Interferon alfa-2b)

Immunomodulator

Merck, USA

merck.com

Approved 1991

Pegasys (Peginterferon alfa-2a)

Immunomodulator

Genentech, USA

gene.com

Approved 2005


Nucleos(t)ide Analogues: Interfere with viral DNA polymerase used for HBV replication

Epivir (Lamivudine)

Inhibits viral DNA polymerase

GlaxoSmithKline (GSK)

gsk.com

Approved 1998

Hepsera (Adefovir dipivoxil)

Inhibits viral DNA polymerase

Gilead Sciences, USA

gilead.com

Approved 2002

Baraclude (Entecavir)

Inhibits viral DNA polymerase

Bristol-Myers Squibb, USA

bms.com

Approved 2005

Tyzeka (Telbivudine)

Inhibits viral DNA polymerase

Novartis, USA

novartis.com

Approved 2006

Viread (Tenofovir)

Inhibits viral DNA polymerase

Gilead Sciences

gilead.com

Approved 2008

Vemlidy (Tenofovir alafenamide/TAF)

Prodrug of tenofovir

Gilead Sciences

gilead.com

Approved Nov. 2016

Levovir (Clevudine)

Inhibits viral DNA polymerase

Bukwang, S. Korea

bukwang.co.kr

Approved 2006 in S. Korea

Zadaxin

Immunomodulator

SciClone, USA

sciclone.com

Approved outside USA



DIRECT ACTING ANTIVIRALS: Targets the virus and interferes in the HBV replication process



TDF Pro Drugs: A modified tenofovir drug that can get into liver cells more easily

TXL (CMX 157)

Prodrug of tenofovir

ContraVir, USA



contravir.com

Phase II



Silencing RNA’s (siRNAs): Interferes and destroys viral RNA

ARB-1467

RNAi gene silencer (1.0)

Arbutus Biopharma, Canada

arbutusbio.com

Phase II

ALN-HBV

RNAi gene silencer

Alnylam, USA

alnylam.com

Preclinical

Hepbarna (BB-HB-331)

RNAi gene silencer

Benitec, Australia

benitec.com

Preclinical

ARB-1740

RNAi gene silencer (2.0)

Arbutus Biopharma

arbutusbio.com

Preclinical

Lunar-HBV

RNAi gene silencer

Arcturus, USA with Janssen of J&J

arcturusrx.com

Preclinical



Entry Inhibitors: Interferes with HBV getting into liver cells

Myrcludex B

Entry inhibitor

Hepatera, Russia with MYR GmbH, Germany

myr-pharma.com

Phase II



Capsid Inhibitors: Interferes with the viral DNA protein shield

Morphothiadin (GLS4)

Capsid inhibitor

HEC Pharma,
PR China

pharm.hec.cn/en

Phase II

NVR 3-778

Capsid inhibitor

Janssen of J&J

janssen.com

Phase II

AIC 649

Capsid inhibitor

AiCuris, Germany

aicuris.com

Phase I

JNJ56136379

Capsid Inhibitor

Janssen of J&J

janssen.com

Phase I

ABI-H0731

Capsid inhibitor

Assembly Biosciences, USA

assemblybio.com

Phase I

AB-423

Capsid inhibitor

Arbutus Biopharma

arbutusbio.com

Preclinical



HBsAg Inhibitors: Interferes with production of HBV surface antigen (sAg)

Rep 2139

sAg inhibitor

REPLICor, Canada

replicor.com

Phase II

Rep 2165

sAg inhibitor

REPLICor

replicor.com

Phase II

RO7020322 (RG7834)

sAg inhibitor

Roche

roche.com

Phase I



Antisense Molecules: Binds to the viral mRNA to prevent it from turning into viral protein

IONIS-HBVRx (GSK3228836)

Viral protein inhibitor

Ionis Pharma, USA with GSK

ionispharma.com

Phase I

IONIS-HBVLRx (GSK33389404)

Viral protein inhibitor

Ionis Pharma with GSK

ionispharma.com

Phase I



INDIRECT ACTING ANTIVIRALS: Targets the human immune system to attack the HBV virus



Therapeutic Vaccines: Vaccine technology used to stimulate the immune system as a treatment

GS 4774

Therapeutic vaccine

Gilead with GlobeImmune, USA

gilead.com

Phase II

INO-1800

Therapeutic vaccine

Inovio, USA

inovio.com

Phase I

HB-110

Therapeutic vaccine

Ichor, USA with Janssen

ichorms.com

Phase I

TG1050

Therapeutic vaccine

Transgene, France

transgene.com

Phase I

HepTcell

Therapeutic vaccine

Altimmune, USA

altimmune.com

Phase I

TomegaVax HBV

Therapeutic vaccine

TomegaVax, USA

tomegavax.com

Preclinical



Innate Immune Defense Pathway: Compounds that activate the innate immune system

GS 9620

TLR-7 agonist

Gilead Sciences

gilead.com

Phase II

RO6864018 (RG7795, ANA773)

TLR-7 agonist

Roche

roche.com

Phase II

SB9200

RIG -1 and NOD2 agonist

Spring Bank Pharmaceuticals, USA

springbankpharm.com

Phase II



Host Acting Pathway: Compounds that induce programmed cell death (apoptosis)

EYP001

FXR agonist

Enyo Pharma, France

enyopharma.com

Phase I

CRV 431 (CPI 431-32)

Ciclofillin inhibitor

ContraVir

contravir.com

Preclinical



HEPATITIS DELTA VIRUS (HDV)

Myrcludex B

Entry inhibitor

MYR-GmbH

myr-pharma.com

Phase II

Lonafarnib

Prenylation inhibitor

Eiger Biopharma, USA

eigerbio.com

Phase II

Pegylated Interferon Lambda

Immunomodulator

Eiger Biopharma, USA

eigerbio.com

Phase II

Rep 2139

HBsAg inhibitor

REPLICor

replicor.com

Phase II

ALN-HDV

RNAi gene silencer

Alnylam

alnylam.com

Preclinical

作者: rxsm    时间: 2017-3-1 22:57

怎么都是番文?
作者: kite2002005    时间: 2017-3-3 22:45

都不如arc520,虽然它已经死了
作者: TRUMPHILARY    时间: 2017-3-3 23:31

这是一个有价值的网站,可以看看
作者: yelanglms    时间: 2017-3-4 15:47

rxsm 发表于 2017-3-1 22:57
怎么都是番文?

英文没关系啊,只要认识那几个字母就行了。

作者: yelanglms    时间: 2017-3-4 15:49

rxsm 发表于 2017-3-1 22:57
怎么都是番文?

几个字母组合就是药的名字,然后就是所在临床试验的期数,或者哪一年批准上市的,还有就是哪个公司研究的,知道这几个就行了,其它的不知道也无所谓。

作者: yelanglms    时间: 2017-3-4 15:52

本帖最后由 yelanglms 于 2017-3-5 07:29 编辑

从这个网址可以看到有很多药物进入临床I期或II期,可惜没有进入临床III的。
作者: rxsm    时间: 2017-3-4 18:23

回复 yelanglms 的帖子

哦!学习了。谢谢!





欢迎光临 肝胆相照论坛 (http://hbvhbv.info/forum/) Powered by Discuz! X1.5