白细胞介素-27在预测慢性乙型肝炎感染中自发HBeAg血清学转换

StephenW

The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection
Authors

    Accepted manuscript online: 23 January 2017Full publication history
    DOI: 10.1111/liv.13372View/save citation
    Cited by: 0 articles

    This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.13372

Abstract
Background and Aims

Hepatitis B e seroconversion, associated with preceding hepatic inflammation, marks the transition from immune active to residual phase in the natural disease history of chronic hepatitis B. Recently, interleukin-27 has been reported to be associated with hepatic inflammation in hepatitis B infection. We aimed to evaluate the role of interleukin-27 in predicting spontaneous e seroconversion in chronic hepatitis B.
Methods

142 treatment-naive hepatitis B patients with positive e antigen were recruited. Interleukin-27, hepatitis B viral DNA levels and liver function parameters, were measured on presentation. Patients who had spontaneous e seroconversion within 3 years of follow-up were compared with those without e seroconversion within the same period of time. Factors predictive of spontaneous e seroconversion were identified.

Results

Of the 142 patients (M:F= 80:62, median age: 31), 44 (31%) had spontaneous e seroconversion within 3 years of follow-up. Multivariate analyses revealed that younger age, lower viral DNA and lower interleukin-27 levels on presentation independently predicted spontaneous e seroconversion: the rate was significantly higher in patients aged <31 (OR:11.022, 95% CI:3.658-33.205; P <0.001), viral DNA <5 log IU/mL (OR: 2.311, 95% CI: 1.049-5.091; P=0.038) and interleukin-27 <67.3 pg/mL (OR: 3.276, 95% CI: 1.257-8.536; P=0.015). Among patients with all these 3 favourable factors on presentation, 77% of them underwent spontaneous e seroconversion within 3 years.

Conclusions

Low interleukin-27 levels were associated with early e seroconversion. The combination of baseline interleukin-27 <67.3 pg/mL and viral DNA <5 log IU/mL in young patients was useful for predicting early spontaneous e seroconversion in treatment naïve chronic hepatitis B patients.

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StephenW

白细胞介素-27在预测慢性乙型肝炎感染中自发HBeAg血清学转换的作用
作者

    在线接受手稿：2017年1月23日完整的出版历史
    DOI：10.1111 / liv.13372查看/保存引文
    引用：0文章

    本文已被接受发布并经过完整的同行评审，但没有通过复制，排版，分页和校对过程，这可能导致此版本和记录版本之间的差异。请引用本文作为doi：10.1111 / liv.13372

抽象
背景和目的

乙型肝炎病毒血清转化与先前的肝脏炎症相关，标志着在慢性乙型肝炎的自然病史中从免疫活性向残留相的转变。最近，据报道白细胞介素-27与乙型肝炎感染的肝炎症有关。我们的目的是评估白细胞介素-27在预测慢性乙型肝炎的自发性血清学转换中的作用。
方法

招募142名具有阳性e抗原的未治疗的乙型肝炎患者。测量白细胞介素-27，乙型肝炎病毒DNA水平和肝功能参数。将在3年内随访期间发生自发性血清转换的患者与在同一时间段内无血清学转换的患者进行比较。鉴定了预测自发性血清转化的因素。

结果

在142例患者（M：F = 80:62，中位年龄：31）中，44例（31％）在随访的3年内发生自发性血清转换。多变量分析显示年龄较小，病毒DNA较低和白细胞介素-27水平降低独立预测自发性血清学转换：<31（OR：11.022,95％CI：3.658-33.205; P <0.001 ），病毒DNA <5log IU / mL（OR：2.311,95％CI：1.049-5.091; P = 0.038）和白细胞介素-27 <67.3pg / mL（OR：3.276,95％CI：1.257-8.536; P = 0.015）。在所有这3个有利因素的患者中，77％的患者在3年内进行自发性血清学转换。

结论

低白细胞介素-27水平与早期e血清转换有关。在年轻患者中基线白细胞介素-27 <67.3pg / mL和病毒DNA <5log IU / mL的组合可用于预测早期慢性乙型肝炎患者的早期自发性血清转换。

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MP4

白细胞介素27（IL-27）属于IL6/IL12细胞因子家族中最新成员，是一个由IL12亚基P40相关蛋白EBI和IL12亚基P35相关蛋白P28共同构成的新型异源二聚体细胞因子