The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection
Authors
Accepted manuscript online: 23 January 2017Full publication history
DOI: 10.1111/liv.13372View/save citation
Cited by: 0 articles
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Abstract
Background and Aims
Hepatitis B e seroconversion, associated with preceding hepatic inflammation, marks the transition from immune active to residual phase in the natural disease history of chronic hepatitis B. Recently, interleukin-27 has been reported to be associated with hepatic inflammation in hepatitis B infection. We aimed to evaluate the role of interleukin-27 in predicting spontaneous e seroconversion in chronic hepatitis B.
Methods
142 treatment-naive hepatitis B patients with positive e antigen were recruited. Interleukin-27, hepatitis B viral DNA levels and liver function parameters, were measured on presentation. Patients who had spontaneous e seroconversion within 3 years of follow-up were compared with those without e seroconversion within the same period of time. Factors predictive of spontaneous e seroconversion were identified.
Results
Of the 142 patients (M:F= 80:62, median age: 31), 44 (31%) had spontaneous e seroconversion within 3 years of follow-up. Multivariate analyses revealed that younger age, lower viral DNA and lower interleukin-27 levels on presentation independently predicted spontaneous e seroconversion: the rate was significantly higher in patients aged <31 (OR:11.022, 95% CI:3.658-33.205; P <0.001), viral DNA <5 log IU/mL (OR: 2.311, 95% CI: 1.049-5.091; P=0.038) and interleukin-27 <67.3 pg/mL (OR: 3.276, 95% CI: 1.257-8.536; P=0.015). Among patients with all these 3 favourable factors on presentation, 77% of them underwent spontaneous e seroconversion within 3 years.
Conclusions
Low interleukin-27 levels were associated with early e seroconversion. The combination of baseline interleukin-27 <67.3 pg/mL and viral DNA <5 log IU/mL in young patients was useful for predicting early spontaneous e seroconversion in treatment naïve chronic hepatitis B patients.
This article is protected by copyright. All rights reserved. 作者: StephenW 时间: 2017-1-26 16:04
在142例患者(M:F = 80:62,中位年龄:31)中,44例(31%)在随访的3年内发生自发性血清转换。多变量分析显示年龄较小,病毒DNA较低和白细胞介素-27水平降低独立预测自发性血清学转换:<31(OR:11.022,95%CI:3.658-33.205; P <0.001 ),病毒DNA <5log IU / mL(OR:2.311,95%CI:1.049-5.091; P = 0.038)和白细胞介素-27 <67.3pg / mL(OR:3.276,95%CI:1.257-8.536; P = 0.015)。在所有这3个有利因素的患者中,77%的患者在3年内进行自发性血清学转换。
结论
低白细胞介素-27水平与早期e血清转换有关。在年轻患者中基线白细胞介素-27 <67.3pg / mL和病毒DNA <5log IU / mL的组合可用于预测早期慢性乙型肝炎患者的早期自发性血清转换。