arc520 好资料 必看

newchinabok

http://files.shareholder.com/dow ... ster_2015_Final.pdf

fs2002

看不懂，好心人翻译一下呗

newchinabok

回复 fs2002 的帖子

文字可复制，去百度翻译译吧

jinabest

结论：arc520对大三阳猩猩降低表抗效果明显，对小三阳猩猩效果不明显。arc520在4mg剂量仍然是耐受的。多种证据表明整合dna是产生表抗的主要来源，尤其对于小三阳。

ivanich

人还是猩猩

齐欢畅2

jinabest 发表于 2015-11-10 13:03
结论：arc520对大三阳猩猩降低表抗效果明显，对小三阳猩猩效果不明显。arc520在4mg剂量仍然是耐受的。多种 ...

整合dna是产生表抗的主要来源，

StephenW

齐欢畅2 发表于 2015-11-10 21:17
整合dna是产生表抗的主要来源，

整合dna是产生表抗的主要来源 - 整合dna是产生表抗一个来源, 不是主要来源.

齐欢畅2

ARC-520 will continue development including focus on the significant market of e-antigen positive treatment-naïve chronic HBV patients. ARC-521 is being developed to target cccDNA and also, integrated DNA, which appears to be a more significant producer of HBsAg in patients who have been treated with NUCs or who are e-antigen negative. In HBeAg-negative chimps predicted to have higher levels of integrated DNA, administration of the integrant-targeted siRNA in ARC-521 led to 99% (2 logs) of additional HBsAg reduction. The Company expects to file an IND or equivalent for ARC-521 by mid-2016.

齐欢畅2

ARC-521

administration of the integrant-targeted siRNA in ARC-521 led to 99% (2 logs) of additional HBsAg reduction. The Company expects to file an IND or equivalent for ARC-521 by mid-2016.

齐欢畅2

StephenW 发表于 2015-11-10 21:28
整合dna是产生表抗的主要来源 - 整合dna是产生表抗一个来源, 不是主要来源. ...