乙型肝炎免疫接种的青少年婴幼儿：意大利17年 随访研究。

StephenW

http://www.ncbi.nlm.nih.gov/pubmed/24528380

Clin Microbiol Infect.
2014 Feb 16.
doi: 10.1111/1469-0691.12591. [Epub ahead of print]

Hepatitis B immunity in teenagers vaccinated as infants: an Italian 17-year
follow-up study.

Spada E, Romanò L, Tosti ME, Zuccaro O, Paladini S, Chironna M, Coppola
RC, Cuccia M, Mangione R, Marrone F, Negrone FS, Parlato A, Zamparo E,
Zotti CM, Mele A, Zanetti AR; The Study Group.

Author information

Abstract
We assessed the persistence of anti-HBs antibody and immune memory in a
cohort of 571 teenagers vaccinated against hepatitis B as infants, 17 years
earlier. Vaccinees were followed-up in 2003 and in 2010, i.e. 10 years and
17 years after primary vaccination, respectively. When tested in 2003, 199
vaccinees (group A) had anti-HBs <10 mIU/ml and were boosted, 372 (group
B) were not boosted because they had anti-HBs ≥10 mIU/ml (n=344) or
refused booster (n=28) despite anti-HBs <10 mIU/ml. In 2010, 72.9%
(416/571) participants had anti-HBs ≥10 mIU/ml (67.3% in group A vs 75.8%
in group B; p=0.03).The geometric mean concentrations (GMCs) were similar
in both groups. Between 2003 and 2010, anti-HBs concentrations in
previously boosted individuals markedly declined with GMC dropping from 486
to 27.7 mIU/ml (p<0.001). Fifteen vaccinees showed a markedly increase of
antibody possibly due to natural booster. In 2010, 96 individuals (37 of
group A and 59 of group B) with anti-HBs <10 mIU/ml were boosted; all
vaccinees of the former group and all but two of the latter had an
anamnestic response. Post-booster GMC was higher in group B (895.6 vs 492.2
mIU/ml: p=0.039). This finding shows that the immune memory for HBsAg
persists beyond the time at which anti-HBs disappears, conferring long-term
protection.

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StephenW

http://www.ncbi.nlm.nih.gov/pubmed/24528380

临床微生物传染。
2014年2月16日。
DOI ： 10.1111/1469-0691.12591 。 [检索策略]

乙型肝炎免疫接种的青少年婴幼儿：意大利17年
随访研究。

斯帕达E，罗马诺L， TOSTI ME， Zuccaro O，帕拉迪尼S， Chironna M，科波拉
RC ，库恰M，曼焦R，的Marrone楼Negrone FS ，帕拉托A， Zamparo E，
ZOTTI CM ，迈乐A，萨内蒂分析纯;研究组。

作者信息

摘要
我们评估了抗-HBs抗体的持久性和免疫记忆的
571青少年人群接种乙肝为婴幼儿，17岁
更早。接种随访在2003年和2010年，即10年，
后17年主要的疫苗接种，分别。当在2003年， 199测试
疫苗接种者（A组）有抗-HBs < 10 MIU / ml和受到提振， 372 （组
B）并没有提高，因为他们有抗-HBs ≥ 10 MIU /毫升（N = 344）或
拒绝助推器（N = 28 ） ，尽管抗-HBs < 10 MIU /毫升。 2010年， 72.9 ％
（ 571分之416 ）参加者抗-HBs ≥ 10 MIU /毫升（ 67.3 ％ ，A组与75.8 ％
在B组，P = 0.03 ）的几何平均浓度（系膜细胞）相似
在两个组。 2003年至2010年，抗-HBs浓度
此前提振个人明显下降与GMC的下落从486
27.7 MIU /毫升（ P <0.001） 。十五接种表现出的显着增加
抗体可能是由于自然的助推器。 2010年， 96个人37 （
与抗-HBs A组和B组第59号） < 10 MIU / ml的提振;所有
前一组的接种和所有，但两个后者有一个
回忆应答。后助推器GMC明显高于B组（ 895.6与492.2
MIU / ml的： P = 0.039） 。这一发现表明，免疫记忆的乙肝表面抗原
持续超过在其中抗-HBs消失的时候，赋予长期
保护。

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