Clin Microbiol Infect.
2014 Feb 16.
doi: 10.1111/1469-0691.12591. [Epub ahead of print]
Hepatitis B immunity in teenagers vaccinated as infants: an Italian 17-year
follow-up study.
Spada E, Romanò L, Tosti ME, Zuccaro O, Paladini S, Chironna M, Coppola
RC, Cuccia M, Mangione R, Marrone F, Negrone FS, Parlato A, Zamparo E,
Zotti CM, Mele A, Zanetti AR; The Study Group.
Author information
Abstract
We assessed the persistence of anti-HBs antibody and immune memory in a
cohort of 571 teenagers vaccinated against hepatitis B as infants, 17 years
earlier. Vaccinees were followed-up in 2003 and in 2010, i.e. 10 years and
17 years after primary vaccination, respectively. When tested in 2003, 199
vaccinees (group A) had anti-HBs <10 mIU/ml and were boosted, 372 (group
B) were not boosted because they had anti-HBs ≥10 mIU/ml (n=344) or
refused booster (n=28) despite anti-HBs <10 mIU/ml. In 2010, 72.9%
(416/571) participants had anti-HBs ≥10 mIU/ml (67.3% in group A vs 75.8%
in group B; p=0.03).The geometric mean concentrations (GMCs) were similar
in both groups. Between 2003 and 2010, anti-HBs concentrations in
previously boosted individuals markedly declined with GMC dropping from 486
to 27.7 mIU/ml (p<0.001). Fifteen vaccinees showed a markedly increase of
antibody possibly due to natural booster. In 2010, 96 individuals (37 of
group A and 59 of group B) with anti-HBs <10 mIU/ml were boosted; all
vaccinees of the former group and all but two of the latter had an
anamnestic response. Post-booster GMC was higher in group B (895.6 vs 492.2
mIU/ml: p=0.039). This finding shows that the immune memory for HBsAg
persists beyond the time at which anti-HBs disappears, conferring long-term
protection.
This article is protected by copyright. All rights reserved. 作者: StephenW 时间: 2014-2-21 09:31
http://www.ncbi.nlm.nih.gov/pubmed/24528380
临床微生物传染。
2014年2月16日。
DOI ： 10.1111/1469-0691.12591 。 [检索策略]