喝咖啡，巧克力和正常ALT?

StephenW

Association between elevated coffee consumption and
daily chocolate intake with normal liver enzymes in
HIV-HCV infected individuals: Results from the ANRS
CO13 HEPAVIH cohort study
M. Patrizia Carrieri 1,2,3,⇑,, Caroline Lions 1,2,3,, Philippe Sogni 4,5, Maria Winnock 6,
Perrine Roux 1,2,3, Marion Mora 1,2,3, Philippe Bonnard 7, Dominique Salmon 8,9,
François Dabis 6, Bruno Spire 1,2,3,
the ANRS CO13 HEPAVIH Study Group
1 INSERM, U912 (SESSTIM), Marseille, France;
2 Aix Marseille Univ, IRD, UMR-S912, Marseille, France;
3 ORS PACA, Observatoire
Régional de la Santé Provence Alpes Côte d’Azur, Marseille, France;
4 Institut Cochin, Université Paris-Descartes, INSERM U567-CNRS
(UMR 8104), Paris, France;
5 APHP, Hôpital Cochin, Service d’Hépatologie, Paris, France;
6 INSERM, U897 and ISPED, Université
Victor Segalen, Bordeaux, France;
7 Maladies Infectieuses, Hôpital Tenon, UPMC Univ Paris 06, UPMC Paris Liver Center,
Paris, France;
8 Service des Maladies Infectieuses et Tropicales, Hôpital Cochin, AP-HP, Paris, France;
9 Université Paris Descartes, Paris, France


Background & Aims
We used longitudinal data from the ANRS CO13 HEPAVIH cohort study of HIV-HCV co-infected individuals to investigate whether polyphenol rich food intake through coffee and/or daily chocolate consumption could play a role in reducing liver enzymes levels.
Methods

Longitudinal data collection included self-administered questionnaires and medical data (aspartate aminotransferase (AST) and alanine aminotransferase (ALT) liver enzymes). Two analyses were performed to assess the association between coffee (⩾3 cups a day) and daily chocolate intake and abnormal values of AST and ALT (AST or ALT >2.5 × upper normal limit (UNL)) (N = 990) over time, after adjustment for known correlates. Logistic regression models based on generalized estimating equations were used to take into account the correlations between repeated measures and estimate adjusted odds ratio.
Results

After adjustment, patients reporting elevated coffee consumption and daily chocolate intake were less likely to present abnormal ALT (OR = 0.65; p = 0.04 and OR = 0.57; p = 0.04, for coffee and chocolate respectively), while only patients reporting elevated coffee consumption were less likely to have abnormal AST values (p = 0.05). Nevertheless, the combined indicator of coffee and chocolate intake was most significantly associated with approximately 40% reduced risk of abnormal liver enzymes (p = 0.003 for AST; p = 0.002 for ALT).
Conclusions

Elevated coffee consumption and daily chocolate intake appear to be associated with reduced levels of liver enzymes in HIV-HCV co-infected patients. Further experimental and observational research is needed to better understand the role that polyphenol intake or supplementation can play on liver disease and liver injury.

StephenW

高架咖啡消费之间的关联
每天摄入巧克力与正常肝酶
HIV-HCV感染的个体：结果从ANRS
CO13 HEPAVIH队列研究
M.帕特里齐亚Carrieri 1,2,3 ， ⇑ ， ？ ，卡罗琳狮子1,2,3 ， ？ ，菲利普Sogni酒店4,5 ，玛丽亚Winnock 6 ，
Perrine中鲁1,2,3 ，马里昂莫拉1,2,3 ，菲利普·波纳尔7 ，多米尼克三文鱼8,9 ，
弗朗索瓦Dabis 6 ，布鲁诺石塔1,2,3 ，
该ANRS CO13 HEPAVIH研究小组
1 INSERM ， U912 （ SESSTIM ） ，法国马赛;
2艾克斯马赛大学，税务局， UMR- S912 ，法国马赛;
3 ORS PACA ，天文台
区域德拉桑特普罗旺斯 - 阿尔卑斯 - 蓝色海岸，法国马赛;
4科钦研究所，巴黎大学，笛卡尔， INSERM U567 - CNRS
（ UMR 8104 ） ，法国巴黎;
5 APHP ，科钦总医院，服务D' Hépatologie ，巴黎，法国;
6 INSERM ， U897和ISPED ， UNIVERSITE
谢阁兰，法国波尔多;
7弊端Infectieuses ，总医院榫， UPMC大学巴黎06 ， UPMC巴黎肝病中心，
巴黎，法国;
8服务DES弊端Infectieuses等Tropicales ，科钦总医院， AP- HP ，巴黎，法国;
9巴黎大学笛卡尔，巴黎，法国


背景及宗旨
我们采用纵向数据免受HIV - HCV合并感染者的ANRS CO13 HEPAVIH队列研究，以调查是否通过咖啡和/或每日食用巧克力多酚丰富的食物的摄入量可降低肝酶水平的作用。
方法

纵向数据采集包括自填式问卷和医疗数据（谷草转氨酶（AST ）和丙氨酸转氨酶（ALT ）肝酶） 。两种分析，以评估之间的咖啡（ ⩾ 3杯的日子）和每日摄入巧克力和AST和ALT值异常（ AST或ALT > 2.5 ×正常值上限（ UNL ） ）的相关（N = 990 ），随着时间的推移，调整为已知的相关因素之后。基于广义估计方程Logistic回归模型来考虑重复测量和估算调整后的比值比之间的关系。
结果

调整后，患者报告的升高饮用咖啡和巧克力的每日摄入量是不太可能呈现ALT异常（ OR = 0.65 ，P = 0.04， OR = 0.57 ，P = 0.04 ，分别为咖啡和巧克力） ，而只有患者报告高架咖啡消费不太可能有AST异常值（ P = 0.05） 。 （ P = 0.002 ALT P = 0.003助攻）尽管如此，咖啡和巧克力的摄入量指标相结合是最显著与肝酶异常约40％的风险降低相关。
结论

高架饮用咖啡和巧克力的每日摄入量似乎与肝酶在HIV - HCV合并感染的患者水平降低相关。进一步的实验和观察性研究，需要更好地理解多酚摄入或补充可以对肝病和肝损伤发挥的作用。