Association between elevated coffee consumption and
daily chocolate intake with normal liver enzymes in
HIV-HCV infected individuals: Results from the ANRS
CO13 HEPAVIH cohort study
M. Patrizia Carrieri 1,2,3,⇑,, Caroline Lions 1,2,3,, Philippe Sogni 4,5, Maria Winnock 6,
Perrine Roux 1,2,3, Marion Mora 1,2,3, Philippe Bonnard 7, Dominique Salmon 8,9,
François Dabis 6, Bruno Spire 1,2,3,
the ANRS CO13 HEPAVIH Study Group
1 INSERM, U912 (SESSTIM), Marseille, France;
2 Aix Marseille Univ, IRD, UMR-S912, Marseille, France;
3 ORS PACA, Observatoire
Régional de la Santé Provence Alpes Côte d’Azur, Marseille, France;
4 Institut Cochin, Université Paris-Descartes, INSERM U567-CNRS
(UMR 8104), Paris, France;
5 APHP, Hôpital Cochin, Service d’Hépatologie, Paris, France;
6 INSERM, U897 and ISPED, Université
Victor Segalen, Bordeaux, France;
7 Maladies Infectieuses, Hôpital Tenon, UPMC Univ Paris 06, UPMC Paris Liver Center,
Paris, France;
8 Service des Maladies Infectieuses et Tropicales, Hôpital Cochin, AP-HP, Paris, France;
9 Université Paris Descartes, Paris, France
Background & Aims
We used longitudinal data from the ANRS CO13 HEPAVIH cohort study of HIV-HCV co-infected individuals to investigate whether polyphenol rich food intake through coffee and/or daily chocolate consumption could play a role in reducing liver enzymes levels.
Methods
Longitudinal data collection included self-administered questionnaires and medical data (aspartate aminotransferase (AST) and alanine aminotransferase (ALT) liver enzymes). Two analyses were performed to assess the association between coffee (⩾3 cups a day) and daily chocolate intake and abnormal values of AST and ALT (AST or ALT >2.5 × upper normal limit (UNL)) (N = 990) over time, after adjustment for known correlates. Logistic regression models based on generalized estimating equations were used to take into account the correlations between repeated measures and estimate adjusted odds ratio.
Results
After adjustment, patients reporting elevated coffee consumption and daily chocolate intake were less likely to present abnormal ALT (OR = 0.65; p = 0.04 and OR = 0.57; p = 0.04, for coffee and chocolate respectively), while only patients reporting elevated coffee consumption were less likely to have abnormal AST values (p = 0.05). Nevertheless, the combined indicator of coffee and chocolate intake was most significantly associated with approximately 40% reduced risk of abnormal liver enzymes (p = 0.003 for AST; p = 0.002 for ALT).
Conclusions
Elevated coffee consumption and daily chocolate intake appear to be associated with reduced levels of liver enzymes in HIV-HCV co-infected patients. Further experimental and observational research is needed to better understand the role that polyphenol intake or supplementation can play on liver disease and liver injury. 作者: StephenW 时间: 2013-12-16 17:51
调整后，患者报告的升高饮用咖啡和巧克力的每日摄入量是不太可能呈现ALT异常（ OR = 0.65 ，P = 0.04， OR = 0.57 ，P = 0.04 ，分别为咖啡和巧克力） ，而只有患者报告高架咖啡消费不太可能有AST异常值（ P = 0.05） 。 （ P = 0.002 ALT P = 0.003助攻）尽管如此，咖啡和巧克力的摄入量指标相结合是最显著与肝酶异常约40％的风险降低相关。
结论