Effects of entecavir and Shenxian Yiganling combination therapy on patients with

StephenW

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Feb;32(2):180-2.
[Effects of entecavir and Shenxian Yiganling combination therapy on patients with HBeAg-positive chronic hepatitis B for 48 weeks]. [Article in Chinese]
Zhang T, Wang Y, Sun KW.
Source
Department of Infectious Diseases, First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha (410007).

Abstract
OBJECTIVE: To evaluate of the efficacy and safety of entecavir (ETV) combined with Shenxian Yiganling (SY) versus ETV therapy on patients with HBeAg-positive chronic hepatitis B (CHB) for 48 weeks.
METHODS: One hundred and sixty-four CHB patients were assigned to two groups with the cohort study: the ETV combined with SY treatment group and the ETV control group. The alanine aminotransferase (ALT), the undetectable HBV DNA level, and HBeAg negative conversion rate, and HBeAg serological negative conversion rate were observed before and after treatment.
RESULTS: At week 48, there was no significant difference in the normalization of ALT levels (70.00% vs 67.61%, P > 0.05) and undetectable HBV DNA levels (72.50% vs 73.24%, P > 0.05) between the two groups. There was significant difference in the HBeAg negative conversion rate (39.44% vs 23.75%) and HBeAg serological negative conversion rate (32.39% vs 15.00%) (both P < 0.05).
CONCLUSION: ETV combined with SY promoted the HBeAg serological negative conversion rate possibly through the recovery of the immune functions.

StephenW

中国中西医结合杂志。 20120232（2）:180-2。
恩替卡韦和莘县益肝灵联合治疗对HBeAg阳性慢性乙型肝炎患者48周]。
[文章在中国]
张田，王元，孙千瓦。
源

署的传染病，第一附属医院，湖南中医大学，长沙（410007）。
抽象
目的：

恩替卡韦（ETV）的疗效和安全性与莘县益肝灵（SY）与ETV对HBeAg阳性慢性乙型肝炎（CHB）患者48周的治疗相结合的评价。
方法：

一百六十四例慢性乙型肝炎患者被分配到两组队列研究：与SY治疗组和ETV控制组相结合的ETV。观察治疗前后的丙氨酸转氨酶（ALT），检测不到乙肝病毒DNA水平，HBeAg的阴转率和HBeAg血清学阴转率。
结果：

48周时，有没有在ALT水平正常化的显着性差异（70.00％和67.61％，P <0.05）和不到HBV DNA水平两组之间（72.50％和73.24％，P <0.05）。在e抗原阴转率（39.44％和23.75％）和HBeAg血清学阴转率（32.39％和15.00％）（P均<0.05）有显着性差异。
结论：

与SY相结合的ETV进e抗原的血清学阴转率可能通过免疫功能的恢复。