EASL2012:Kinetics of serum hepatitis B surface antigen level in genotype C HBs A

StephenW

Abstract               
                                

Title	Kinetics of serum hepatitis B surface antigen level in genotype C HBs Ag serocleared carriers
Speaker:	Shinya   Nagaoka
Author:	S. Nagaoka*, H. Yatsuhashi, Y. Kugiytama, K. Ogihara, S. Bekki, S. Hashimoto, M. Ohtani, S.K. Bae, A. Saeki, S. Abiru, A. Komori, H. Ishibashi
Affiliation:	Clinical Research Center, National Nagasaki Medical Center, Omura, Japan. *[email protected]
Background and aims: Serum levels of hepatitis B surface antigen (HBsAg) decrease gradually during chronic hepatitis B virus infection but spontaneous HBsAg seroclearance is rare. We aimed to investigate the kinetics of serum HBsAg level in HBsAg serocleared carriers. Methods: We studied 403 Japanese chronic hepatitis B patients who had been followed for longer than 5 years in our institute. In a mean follow-up of 15 years, 47 patients were confirmed HBsAg seoclearance. The average annual rate of HBsAg clearance was 0.78%. Serum levels of HBsAg were measured annually using a HISCL HBsAg assay based on CLEIA developed by Sysmex corporation (Kobe,Japan). The assay had a quantitative range of 0.03 to 2500 IU/ml. End titer was determined by diluting samples with normal human serum when initial results exceeded the upper limit of the assay range. Results: The median age of patients with HBsAg seroclearance was 56 years (range 35-68 years). 37 patients (78%) were male. 46 patients (98%) had HBV genotype C-infection. Median HBsAg titer was 1000 IU/ml at 11.27 years before HBsAg seroclearance. 100 IU/ml and 1.0 IU/ml were at 5.03 years and 1.23 years before seroclearance, respectively. The present study showed that median HBsAg level of 100 to 1000 IU/ ml declined -0.16log IU/ml/year, that of 1.0 to 100 IU/ml declined -0.53 logIU/ml/year and that of < 1.0 IU/ml declined -1.22 log/ml/year. Conclusions: The lower serum HBsAg level could accelerate HBsAg decrease. It took about 5 years to achieve HBs Ag seroclearance after HBsAg level reached 100 IU/ml in genotype C HBsAg serocleared carriers.

StephenW

血清乙型肝炎表面抗原水平在C基因型HBs的银标题动力学serocleared运营商
主讲人：长冈伸
作者：S.长冈*，H.八桥，Y. Kugiytama，K.荻原，S. Bekki，与桥本龙太郎，M.大谷，SK裴勇俊，佐伯答S. Abiru，A.小森，H.的石桥
单位：临床研究中心，日本国立长崎医疗中心，大村。 * [email protected]
背景与目的：乙型肝炎表面抗原（HBsAg）血清逐渐下降，在慢性乙肝病毒感染，但自发的HBsAg廓清是罕见的。我们的目的是探讨乙肝表面抗原serocleared携带者血清HBsAg水平的动力学。
方法：我们研究了403日本慢性乙型肝炎患者已超过5年在我院。在平均随访15年，47例被证实，乙肝表面抗原seoclearance。 HBsAg清除的平均年增长率为0.78％。的HBsAg血清测定每年使用HISCL乙肝表面抗原检测的基础上希森美康公司（日本神户）开发CLEIA。该法有0.03至2500 IU / ml的定量范围。结束滴度测定稀释与正常人血清样品时，初步结果超出检测范围上限。
结果：乙肝表面抗原血清廓清患者的年龄中位数为56岁（范围35-68岁）。 37例（78％）为男性。 HBV C基因型感染的46例（98％）。表面抗原滴度中位数为1000 IU / ml的乙肝表面抗原血清廓清之前，在11.27年。 100国际单位/毫升1.0国际单位/毫升，5.03岁和1.23岁之前，廓清。目前的研究表明，HBsAg水平中位数为100至1000国际单位/毫升下降-0.16log IU /毫升/年，1.0至100 IU /毫升下降-0.53 logIU /毫升/年，<1.0 IU /毫升下降-1.22日志/毫升/年。
结论：血清HBsAg水平较低，HBsAg的下降可能会加速。花了大约5年后实现HBsAg水平达到100 IU /毫升C基因型乙肝表面抗原携带者serocleared HBs的银廓清。

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把握当下

背景和目标: 感染乙肝后HBsAg水平将逐渐下降但血清转换很少 . 本文研究发生血清转换的携带者s抗原动力学变化情况.

方法: 研究403 日本乙肝患者超过5年。随访平均时长为15年，47人发生s血清转换. HBsAg年清除率平均为0.78%. HBsAg血清水平使用基于Sysmex公司(神户,日本)CLEIA HISCL的HISCL HBsAg 评估方法检查 . 评估方法定量范围为0.03 - 2500 IU/ml. 检查值超过初始评估上限值后通过使用正常人类血清稀释样本得到真实检测值.

结果：s抗原血清转换平均年龄56岁 (35-68). 37人男(78%) . 46人(98%) C基因型.
s抗原从 1000 IU/ml 到血清转换需要11.27年,s抗原从100 IU/ml到血清转换需要5.03年,s抗原降从1.0 IU/ml到血清转换需要1.23年.
HBsAg在 100 - 1000 IU/ ml 之间每年降低0.16log IU/ml, 在1.0 to 100 IU/ml之间每年降低0.53 logIU/ml，< 1.0 IU/ml 时每年降低1.22 log/ml.

结论：低定量HBsAg可加速HBsAg 下降.C基因型携带者 HBs Ag下降到 100 IU/ml后大约5年发生血清转换.