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- 2022-12-28
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Abstract
Title | Kinetics of serum hepatitis B surface antigen level in genotype C HBs Ag serocleared carriers | Speaker: | Shinya Nagaoka | Author: | S. Nagaoka*, H. Yatsuhashi, Y. Kugiytama, K. Ogihara, S. Bekki, S. Hashimoto, M. Ohtani, S.K. Bae, A. Saeki, S. Abiru, A. Komori, H. Ishibashi | Affiliation: | Clinical Research Center, National Nagasaki Medical Center, Omura, Japan. *[email protected] | Background and aims: Serum levels of hepatitis B surface antigen (HBsAg) decrease gradually during chronic hepatitis B virus infection but spontaneous HBsAg seroclearance is rare. We aimed to investigate the kinetics of serum HBsAg level in HBsAg serocleared carriers.
Methods: We studied 403 Japanese chronic hepatitis B patients who had been followed for longer than 5 years in our institute. In a mean follow-up of 15 years, 47 patients were confirmed HBsAg seoclearance. The average annual rate of HBsAg clearance was 0.78%. Serum levels of HBsAg were measured annually using a HISCL HBsAg assay based on CLEIA developed by Sysmex corporation (Kobe,Japan). The assay had a quantitative range of 0.03 to 2500 IU/ml. End titer was determined by diluting samples with normal human serum when initial results exceeded the upper limit of the assay range.
Results: The median age of patients with HBsAg seroclearance was 56 years (range 35-68 years). 37 patients (78%) were male. 46 patients (98%) had HBV genotype C-infection. Median HBsAg titer was 1000 IU/ml at 11.27 years before HBsAg seroclearance. 100 IU/ml and 1.0 IU/ml were at 5.03 years and 1.23 years before seroclearance, respectively. The present study showed that median HBsAg level of 100 to 1000 IU/ ml declined -0.16log IU/ml/year, that of 1.0 to 100 IU/ml declined -0.53 logIU/ml/year and that of < 1.0 IU/ml declined -1.22 log/ml/year.
Conclusions: The lower serum HBsAg level could accelerate HBsAg decrease. It took about 5 years to achieve HBs Ag seroclearance after HBsAg level reached 100 IU/ml in genotype C HBsAg serocleared carriers. |
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