The clinical implications of hepatitis B virus genotype: Recent advances

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Table 2.                 Comparison of clinical and virological differences among hepatitis B virus genotypes. Due to the unique distribution of HBV genotypes in Asian and Western countries, the available data could only be reliably compared between genotype B and C or genotype A and D

Genotype	B	C	A	D	E–J
ND, no available data.
Clinical characteristics
Modes of transmission	perinatal /vertical	perinatal /vertical	horizontal	horizontal	Horizontal
Tendency of chronicity	Lower	Higher	Higher	Lower	ND
Positivity of HBeAg	Lower	Higher	Higher	Lower	ND
HBeAg seroconversion	Earlier	Later	Earlier	Later	ND
HBsAg seroclearance	More	Less	More	Less	ND
Histologic activity	Lower	Higher	Lower	Higher	ND
Clinical outcome (cirrhosis and hepatocellular carcinoma)	Better	Worse	Better	Worse	Worse in Genotype F
Response to interferon alpha	Higher	Lower	Higher	Lower	Lower in Genotype G
Response to nucleos(t)ide analogues	No significant difference between genotype A to D				ND
Virologic characteristics
Serum HBV DNA level	Lower	Higher	ND	ND	ND
Frequency of precore A1896 mutation	Higher	Lower	Lower	Higher	ND
Frequency of basal core promoter T1762/A1764 mutation	Lower	Higher	Higher	Lower	ND
Frequency of pre-S deletion mutation	Lower	Higher	ND	ND	ND

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06541.x/full