Genotype
| B | C | A | D | E–J |
|
Clinical characteristics |
Modes of transmission | perinatal /vertical | perinatal /vertical | horizontal | horizontal | Horizontal |
Tendency of chronicity | Lower | Higher | Higher | Lower | ND |
Positivity of HBeAg | Lower | Higher | Higher | Lower | ND |
HBeAg seroconversion | Earlier | Later | Earlier | Later | ND |
HBsAg seroclearance | More | Less | More | Less | ND |
Histologic activity | Lower | Higher | Lower | Higher | ND |
Clinical outcome (cirrhosis and hepatocellular carcinoma) | Better | Worse | Better | Worse | Worse in Genotype F |
Response to interferon alpha | Higher | Lower | Higher | Lower | Lower in Genotype G |
Response to nucleos(t)ide analogues | No significant difference between genotype A to D | ND |
Virologic characteristics |
Serum HBV DNA level | Lower | Higher | ND | ND | ND |
Frequency of precore A1896 mutation | Higher | Lower | Lower | Higher | ND |
Frequency of basal core promoter T1762/A1764 mutation | Lower | Higher | Higher | Lower | ND |
Frequency of pre-S deletion mutation | Lower | Higher | ND | ND | ND |