Quantification of hepatitis B surface antigen can help predict spontaneous hepat

StephenW

Eur J Gastroenterol Hepatol. 2012 Jan 23.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22273987
Quantification of hepatitis B surface antigen can help predict spontaneous
hepatitis B surface antigen seroclearance.
Arai M, Togo S, Kanda T,
Fujiwara K, Imazeki F, Yokosuka O.
Source
Department of Medicine and
Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba,
Japan.
Abstract
BACKGROUND AND AIM: The clinical outcomes of hepatitis B
virus (HBV) carriers are favorable following hepatitis B surface antigen
(HBsAg) seroclearance. The aim of this study was to investigate the
clinical course of spontaneous HBsAg seroclearance and the factors
predicting it. METHODS: A total of 423 patients who tested positive for
HBsAg and were referred to Chiba University Hospital between January 1985
and April 2008 were included in the study and the following characteristics
were analyzed: age, sex, status of hepatitis B e antigen, alanine
aminotransferase level, HBV DNA level, number of platelets, HBV genotype,
past treatment with interferon, and HBsAg level. When a nucleotide analog
was used for treatment, we stopped follow-up. Measurement of HBsAg was
performed using the chemiluminescent enzyme immunoassay method and less
than 0.03 IU/ml of HBsAg was designated as HBsAg seroclearance. RESULTS:
The study group included 239 men and 184 women and their average age was
40.5±13.8 years. Twenty-five patients achieved HBsAg seroclearance during
the follow-up period with an incidence rate of 0.97% per year. Multivariate
analysis revealed that HBsAg titer (compared with patients with a low
HBsAg level: odds ratio=0.45, 95% confidence interval: 0.29-0.70) at
baseline was the only predictive factor for HBsAg seroclearance.
CONCLUSION: HBsAg seroclearance occurred at a frequency of 0.97% per year
without the use of a nucleotide analog. HBsAg titer at baseline was the
only predictive factor for HBsAg seroclearance.



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StephenW

欧胃肠肝胆病。 2012年1月23日。
资料来源：http://www.ncbi.nlm.nih.gov/pubmed/22273987
乙肝表面抗原的定量分析，可以帮助预测自发
乙肝表面抗原seroclearance。井男，多哥S，神田T
藤原钾，Imazeki楼横须贺澳医药SourceDepartment
临床肿瘤学，千叶县，千叶大学研究生院医学研究，
日本。摘要背景与目的：乙型肝炎的临床疗效
病毒（HBV）携带者有利于下面的乙肝表面抗原
（HBsAg）的seroclearance。这项研究的目的是调查
临床过程中自发的乙肝表面抗原seroclearance的因素
预测它。方法：共有423例检测呈阳性
HBsAg和千叶大学医院1985年1月之间
2008年4月被列入研究以下几个特点
分析：年龄，性别，乙肝e抗原，丙氨酸，状态
转氨酶水平，HBV DNA水平，血小板的数量，HBV基因型，
干扰素，过去的治疗和HBsAg水平。当一个核苷酸类似物
用于治疗时，我们停止跟进。 HBsAg的测定
使用化学发光酶免疫分析法和少
超过0.03 IU / mL的HBsAg的被指定为乙肝表面抗原seroclearance。结果：
该研究组包括239名男子和184名妇女和她们的平均年龄是
40.5±13.8岁。 25例实现乙肝表面抗原seroclearance
随访期间每年0.97％的发病率。多元
分析显示，低的患者相比，乙肝表面抗原滴度（
HBsAg水平：胜算比= 0.45，95％的置信区间：0.29-0.70）
基线是乙肝表面抗原seroclearance的唯一预测因子。
结论：乙肝表面抗原seroclearance发生频率为每年0.97％
没有一个核苷酸类似物的使用。乙肝表面抗原滴度在基线是
唯一预测因子为乙肝表面抗原seroclearance。

lyq2003526

日本的400多例的hbv感染者追踪调查：
在没有治疗的情况下，HBsAg定量的基线值 是预测 自发的 HBsAg血清学转换的唯一的关系因子。