标题: Quantification of hepatitis B surface antigen can help predict spontaneous hepat [打印本页] 作者: StephenW 时间: 2012-1-30 05:31 标题: Quantification of hepatitis B surface antigen can help predict spontaneous hepat
本帖最后由 风雨不动 于 2012-4-14 14:54 编辑
Eur J Gastroenterol Hepatol. 2012 Jan 23.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22273987
Quantification of hepatitis B surface antigen can help predict spontaneous
hepatitis B surface antigen seroclearance.
Arai M, Togo S, Kanda T,
Fujiwara K, Imazeki F, Yokosuka O.
Source
Department of Medicine and
Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba,
Japan.
Abstract
BACKGROUND AND AIM: The clinical outcomes of hepatitis B
virus (HBV) carriers are favorable following hepatitis B surface antigen
(HBsAg) seroclearance. The aim of this study was to investigate the
clinical course of spontaneous HBsAg seroclearance and the factors
predicting it. METHODS: A total of 423 patients who tested positive for
HBsAg and were referred to Chiba University Hospital between January 1985
and April 2008 were included in the study and the following characteristics
were analyzed: age, sex, status of hepatitis B e antigen, alanine
aminotransferase level, HBV DNA level, number of platelets, HBV genotype,
past treatment with interferon, and HBsAg level. When a nucleotide analog
was used for treatment, we stopped follow-up. Measurement of HBsAg was
performed using the chemiluminescent enzyme immunoassay method and less
than 0.03 IU/ml of HBsAg was designated as HBsAg seroclearance. RESULTS:
The study group included 239 men and 184 women and their average age was
40.5±13.8 years. Twenty-five patients achieved HBsAg seroclearance during
the follow-up period with an incidence rate of 0.97% per year. Multivariate
analysis revealed that HBsAg titer (compared with patients with a low
HBsAg level: odds ratio=0.45, 95% confidence interval: 0.29-0.70) at
baseline was the only predictive factor for HBsAg seroclearance.
CONCLUSION: HBsAg seroclearance occurred at a frequency of 0.97% per year
without the use of a nucleotide analog. HBsAg titer at baseline was the
only predictive factor for HBsAg seroclearance.