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本帖最后由 风雨不动 于 2012-4-14 14:55 编辑
Vaccine. 2012 Jan 10.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22245310
Persistence of long-term immunity to hepatitis B among adolescents
immunized at birth. Chaves SS, Fischer G, Groeger J, Patel PR, Thompson ND,
Teshale EH, Stevenson K, Yano VM, Armstrong GL, Samandari T, Kamili S,
Drobeniuc J, Hu DJ. SourceCenters for Disease Control and Prevention,
Atlanta, GA, USA.
Abstract
The long-term duration of recombinant hepatitis B vaccine-induced immunity
among persons vaccinated starting at birth is still not well understood.
Waning of vaccine-induced immunity could leave young adults at risk of
hepatitis B virus infection due to behavioral or occupational exposures. We
followed a cohort of children immunized starting at birth with a 3-dose
regimen of recombinant hepatitis B vaccine (5mcg, 2.5mcg, 2.5mcg). They
were challenged with a booster dose of the hepatitis B vaccine 10 and 15
years after vaccination to assess anamnestic response as a measure of
persistence of protection. Among 108 participants who had lost protective
antibody levels against hepatitis B, the majority (>70%) had an anamnestic
response to the booster dose; response rates did not decline significantly
between 10 and 15 years follow-up periods. A high antibody concentration
following primary vaccination was independently associated with an
anamnestic response later on in life. Nonetheless, ~20-30% of participants
were unable to mount an immune response after boosting. Hepatitis B
revaccination might be required for persons vaccinated starting at birth if
opportunities for hepatitis B virus exposure exist. Future vaccine
recommendations should be based on studies ascertaining protection against
clinically significant disease.
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发表于 2012-1-28 12:46