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标题: Persistence of long-term immunity to hepatitis B among adolescents [打印本页]

作者: StephenW    时间: 2012-1-28 12:46     标题: Persistence of long-term immunity to hepatitis B among adolescents

本帖最后由 风雨不动 于 2012-4-14 14:55 编辑

Vaccine. 2012 Jan 10.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22245310
Persistence of long-term immunity to hepatitis B among adolescents
immunized at birth. Chaves SS, Fischer G, Groeger J, Patel PR, Thompson ND,
Teshale EH, Stevenson K, Yano VM, Armstrong GL, Samandari T, Kamili S,
Drobeniuc J, Hu DJ. SourceCenters for Disease Control and Prevention,
Atlanta, GA, USA.

Abstract
The long-term duration of recombinant hepatitis B vaccine-induced immunity
among persons vaccinated starting at birth is still not well understood.
Waning of vaccine-induced immunity could leave young adults at risk of
hepatitis B virus infection due to behavioral or occupational exposures. We
followed a cohort of children immunized starting at birth with a 3-dose
regimen of recombinant hepatitis B vaccine (5mcg, 2.5mcg, 2.5mcg). They
were challenged with a booster dose of the hepatitis B vaccine 10 and 15
years after vaccination to assess anamnestic response as a measure of
persistence of protection. Among 108 participants who had lost protective
antibody levels against hepatitis B, the majority (>70%) had an anamnestic
response to the booster dose; response rates did not decline significantly
between 10 and 15 years follow-up periods. A high antibody concentration
following primary vaccination was independently associated with an
anamnestic response later on in life. Nonetheless, ~20-30% of participants
were unable to mount an immune response after boosting. Hepatitis B
revaccination might be required for persons vaccinated starting at birth if
opportunities for hepatitis B virus exposure exist. Future vaccine
recommendations should be based on studies ascertaining protection against
clinically significant disease.



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作者: StephenW    时间: 2012-1-28 12:47

疫苗。 2012年1月10。
资料来源:http://www.ncbi.nlm.nih.gov/pubmed/22245310
在青少年长期免疫对乙肝的持久性
免疫诞生。查韦斯SS,菲舍尔G,Groeger J,帕特尔公关,汤普森ND,
Teshale高血压,史蒂文森K时,矢野虚拟机,阿姆斯特朗GL,Samandari Kamili小号,
Drobeniuc J,胡DJ。 SourceCenters为疾病控制和预防,
美国佐治亚州亚特兰大,的。

摘要
重组乙肝疫苗诱导的免疫长期的持续时间
人在出生时接种开始是仍然不能很好地理解。
疫苗诱导免疫衰退的风险在离开的青壮年
乙肝病毒感染者因行为或职业暴露。我们
跟着人群免疫接种的儿童在出生时开始用3个剂量
重组乙肝疫苗的方案(5mcg,2.5mcg,2.5mcg)。他们
被质疑了乙肝疫苗的助推器剂量10和15
年接种后评估作为衡量回忆应答
保护的持久性。其中108人已经失去了保护的参与者
对B型肝炎的抗体水平,大多数(> 70%)有一个回忆
增强剂;响应率没有显着下降
10至15年的随访时间。抗体浓度高
以下主要疫苗接种与独立相关
在以后的生活回忆应答。尽管如此,20%至30%的参与者
无法安装后刺激免疫反应。 B型肝炎
出生,如果开始接种者可能需要复种
乙肝病毒接触的机会是存在的。未来的疫苗
建议应根据研究确定的保护对
临床上显著的疾病。




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