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本帖最后由 风雨不动 于 2012-4-14 07:17 编辑
HEPDART 2011
ABSTRACT 37
Molecular targeting therapy for our
patients with HCC
M Omata
University of Tokyo and Yamanashi Central and Kita
Hospitals, Japan
Twenty to 30 years ago in Japan, MST (Median
Survival Time) of HCC (Hepatocellular Carcinoma)
was only 9 months (Okuda et al, Cancer 1980). Now,
MST of our patients treated by RFA (Radio Frequency
Ablation) is reaching 90 months or more.
This has been accomplished by 1) careful follow-up of
the high-risk group; HBV/HCV positive patients with
advanced fibrosis, 2) early detention of the tumor by
meticulous imaging techniques using ultrasound and
CT, and 3) curative treatment by surgery or by RFA.
However, there are still many patients who found late
in advanced stages with multiple / huge untreatable
cancer with extrahepatic metastasis; 90% of these are
infected either HCV (80%) or HBV (10%). Sorafenib
(VEGF Receptor blocker) has shown survival benefits
for first time in patients at advanced stages (8 months
placebo vs 11 months).
Future will be how we are able to employee these
molecular targeted drugs to the clinic and hospitals
which has seen tremendous progress of MST
prolongation of patients with HCC in Japan.
摘要:37
为我们的分子靶向治疗
患者与肝癌
中号奥玛特
东京大学和山梨县中央和北
医院,日本
20到30年前,在日本,MST(中位数
生存时间,HCC)(肝癌)
是只有9个月(奥田硕等人,1980年癌症)。现在,
RFA治疗的患者MST(无线电频率
消融)达90个月或以上。
这已经完成:1)小心后续
的高危险群,与HBV/ HCV阳性患者
先进的肝纤维化,2)肿瘤的早期拘留
细致的成像技术,利用超声波和
CT和3)经手术或治疗时发现,RFA。
然而,仍有许多病人发现晚
在与多个/巨大的不治之症高级阶段
肝外转移癌,其中90%
感染丙型肝炎病毒(80%)或乙肝病毒(10%)。索拉非尼
(血管内皮生长因子受体阻断剂)显示的生存利益
患者第一次在高级阶段(8个月
对11个月的安慰剂)。
未来将是我们如何能够向雇员这些
分子靶向药物的诊所和医院
已经看到了巨大进步的MST
延长在日本的肝癌患者。
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