Smallpox vaccine helps cancer survival天花疫苗可帮助战胜肝癌

StephenW

Smallpox vaccine helps cancer survival


It gave us the first ever eradication of an infectious disease; now it
may help defeat liver cancer. Smallpox vaccine has doubled the survival
time of people with advanced liver cancer. The vaccine that eradicated
smallpox consists of a live virus, Vaccinia, with a surprising taste for
tumours. Early experiments in a variety of tumours reported in 2007
suggested that this might make the virus, which has been used safely in
millions of people, a revolutionary cancer treatment. To enhance this
effect, Jennerex Biotherapeutics of San Francisco, gave the live virus
two genetic modifications. One deprives it of an enzyme abundant in
cancer cells, to encourage it to replicate there rather than in normal
cells. The other makes a protein that attracts an attack by the body's
immune system. In a trial in 30 people at a late stage of the liver
cancer hepatocellular carcinoma, those given a high dose of the vaccine
survived for 14 months on average, while those given a low dose survived
seven.

它给我们有史以来第一次消灭传染病;现在
可帮助战胜肝癌。天花疫苗了一倍生存
晚期肝癌的人的时间。该疫苗，根除
一个活病毒，牛痘天花由一个令人惊讶的味道，
肿瘤。在多种肿瘤的早期实验报告在2007年
建议，这可能使病毒，已安全使用
以百万计的人，一个革命性的癌症治疗。为了加强这方面的
效果，Jennerex旧金山的生物疗法，给活病毒
两种遗传修改。一是剥夺了一种酶丰富
癌细胞，鼓励复制，而不是在正常
细胞。其他攻击人体的一种蛋白质，它吸引
免疫系统。在一个30人的审判在晚期肝
癌症肝癌，给予高剂量的疫苗
存活14个月平均，而那些低剂量存活
七。





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