标题: Smallpox vaccine helps cancer survival天花疫苗可帮助战胜肝癌 [打印本页] 作者: StephenW 时间: 2011-11-15 17:16 标题: Smallpox vaccine helps cancer survival天花疫苗可帮助战胜肝癌
本帖最后由 风雨不动 于 2012-4-14 07:42 编辑
Smallpox vaccine helps cancer survival
It gave us the first ever eradication of an infectious disease; now it
may help defeat liver cancer. Smallpox vaccine has doubled the survival
time of people with advanced liver cancer. The vaccine that eradicated
smallpox consists of a live virus, Vaccinia, with a surprising taste for
tumours. Early experiments in a variety of tumours reported in 2007
suggested that this might make the virus, which has been used safely in
millions of people, a revolutionary cancer treatment. To enhance this
effect, Jennerex Biotherapeutics of San Francisco, gave the live virus
two genetic modifications. One deprives it of an enzyme abundant in
cancer cells, to encourage it to replicate there rather than in normal
cells. The other makes a protein that attracts an attack by the body's
immune system. In a trial in 30 people at a late stage of the liver
cancer hepatocellular carcinoma, those given a high dose of the vaccine
survived for 14 months on average, while those given a low dose survived
seven.