[临床表现]在老龄人口,获取与消失HBsAg和抗- HCV

StephenW

<http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02363.x/abstract>
在老龄人口,获取与消失
HBsAg和抗- HCV

Acquirement and disappearance of HBsAg and anti-HCV in an aged population:
a follow-up study in an endemic township

Pei-Shan Tsai1,2,†, Chang-Jung Chang3,4,†, Kow-Tong Chen2, Kuo-Chin
Chang4,5, Shu-Fen Hung5, Jing-Houng Wang4,5, Chao-Hung Hung4,5, Chien-Hung
Chen4,5, Po-Lin Tseng4,5, Kwong-Ming Kee4,5, Yi-Hao Yen4,5, Chin-Chen
Tsai1, Sheng-Nan Lu4,5

Article first published online: 4 NOV 2010

DOI: 10.1111/j.1478-3231.2010.02363.x

© 2010 John Wiley & Sons A/S
Issue

Liver International
Volume 31, Issue 7, pages 971–979, August 2011

Abstract

Background: HBsAg and anti-hepatitis C virus (anti-HCV) are stable markers
and widely used. The seroconversion and seroclearance of HBsAg and anti-HCV
are important for disease control and prognosis of diseases.

Aims: To investigate acquirement and disappearance of HBsAg and anti-HCV in
an endemic area.

Methods: Seven years after a community screening, 1002 of 2909 residents of
Tzukuan Township were recruited. HBsAg, anti-HCV and alanine transaminase
(ALT) were checked in all who participated and hepatitis B virus (HBV) DNA,
anti-HBs, anti-HBc, HCV RNA, anti-HDV and upper abdominal ultrasonography
were studied in different groups.

Results: There were 461 male and 541 female residents with a mean age of
66.7±8.6 years. No new HBsAg carrier was noted and the HBsAg clearance
rate was 1.58% per year. One of the 17 cases with HBsAg clearance had
positive HBV DNA, three had ALT elevation, two had cirrhosis and seven had
anti-HBs seroconversion. Quantitative of HBsAg and HBV DNA were concordant
and 78.1% subjects had low levels of titration. Anti-HBc alone contributed
to 32.1% and was prominent in old age and the anti-HCV-positive group. The
anti-HCV seroconversion rate was only 0.74% per year and household
transmission was the only risk factor. Only 37.5% of cases with anti-HCV
seroconversion had HCV viraemia and the anti-HCV seroreversion rate was
0.63% per year. The anti-HDV seroconversion rate was 0.72% per year and no
subject showed anti-HDV clearance.

Conclusions: Much higher rates of HBsAg seroclearance, anti-HCV
seroreversion and anti-HBc alone were noted in this endemic area and no
subject showed anti-HDV clearance.

StephenW

谷歌翻译，不是100％准确，仅供参考

获取与消失老年人口的HBsAg和抗- HCV消失：
在流行乡镇的后续研究

培山Tsai1，2，†，常荣Chang3，4，†，KOW -塘Chen2，国晋
Chang4，5，淑芬Hung5，郭静Wang4，5，超红Hung4，5，剑虹
Chen4，5，宝琳Tseng4，5，广明Kee4，5日，毅豪Yen4，5，展陈
5，胜南Lu4 Tsai1

文章首先在网上公布：2010年11月4日的

DOI：10.1111/j.1478-3231.2010.02363.x

© 2010威利父子的A / S
发行

肝国际
31卷第7期，第971-979页，2011年8月

摘要

背景：HBsAg和抗丙型肝炎病毒（抗- HCV）是稳定的标记
并广泛使用。 HBsAg和抗- HCV血清学转换和seroclearance
美国疾病控制和疾病的预后很重要。

目的：调查采集和消失，HBsAg和抗- HCV
疾病流行地区。

方法：7年后，一个社区放映的2909居民，1002
Tzukuan乡被招募。检测HBsAg，抗- HCV和谷丙转氨酶
（ALT），在所有参与和乙型肝炎病毒（HBV）DNA检查，
抗- HBs，抗- HBc阳性，丙型肝炎病毒RNA，抗- HDV和上腹部超声
在不同的群体进行了研究。

结果：有461名男性和541名女性居民的平均年龄
66.7 ± 8.6岁。有人指出，没有新的HBsAg携带者HBsAg清除
率为1.58％每年。 17例HBsAg清除之一
积极三人ALT升高，HBV - DNA，两个有肝硬化和七人
抗- HBs血清转换。 HBsAg和HBV DNA定量是一致的
和78.1％的水平低的滴定。抗- HBc单独贡献
32.1％，并在老年和抗- HCV阳性组突出。 “
抗- HCV血清学转换率只有0.74％，每年和家庭
传输是唯一的危险因素。只有37.5％的病例与抗- HCV
血清转换了丙型肝炎病毒血症和抗- HCV seroreversion率
每年0.63％。抗- HDV血清学转换率是0.72％，每​​年并没有
主题表现出抗- HDV关。

结论：对HBsAg seroclearance率要高得多，抗- HCV
seroreversion和抗- HBc单独被注意到并没有在这个流行区
主题表现出抗- HDV关。