Liver International
Volume 31, Issue 7, pages 971–979, August 2011
Abstract
Background: HBsAg and anti-hepatitis C virus (anti-HCV) are stable markers
and widely used. The seroconversion and seroclearance of HBsAg and anti-HCV
are important for disease control and prognosis of diseases.
Aims: To investigate acquirement and disappearance of HBsAg and anti-HCV in
an endemic area.
Methods: Seven years after a community screening, 1002 of 2909 residents of
Tzukuan Township were recruited. HBsAg, anti-HCV and alanine transaminase
(ALT) were checked in all who participated and hepatitis B virus (HBV) DNA,
anti-HBs, anti-HBc, HCV RNA, anti-HDV and upper abdominal ultrasonography
were studied in different groups.
Results: There were 461 male and 541 female residents with a mean age of
66.7±8.6 years. No new HBsAg carrier was noted and the HBsAg clearance
rate was 1.58% per year. One of the 17 cases with HBsAg clearance had
positive HBV DNA, three had ALT elevation, two had cirrhosis and seven had
anti-HBs seroconversion. Quantitative of HBsAg and HBV DNA were concordant
and 78.1% subjects had low levels of titration. Anti-HBc alone contributed
to 32.1% and was prominent in old age and the anti-HCV-positive group. The
anti-HCV seroconversion rate was only 0.74% per year and household
transmission was the only risk factor. Only 37.5% of cases with anti-HCV
seroconversion had HCV viraemia and the anti-HCV seroreversion rate was
0.63% per year. The anti-HDV seroconversion rate was 0.72% per year and no
subject showed anti-HDV clearance.
Conclusions: Much higher rates of HBsAg seroclearance, anti-HCV
seroreversion and anti-HBc alone were noted in this endemic area and no
subject showed anti-HDV clearance.作者: StephenW 时间: 2011-7-11 13:55