[英语研究] Alaska(阿拉斯加)-疫苗消除童年肝癌

StephenW

Hepatology. 2011 May 26. doi: 10.1002/hep.24442. [Epub ahead of print]

Elimination of hepatocellular carcinoma and acute hepatitis B in children
25 years after a hepatitis B newborn and catch-up immunization program.

McMahon BJ, Bulkow LR, Singleton RJ, Williams J, Snowball M, Homan C,
Parkinson AJ.

Source
Liver Disease and Hepatitis Program, Alaska Native Tribal Health
Consortium, Anchorage Alaska; Arctic Investigations Program, Division of
Preparedness and Emerging Infections, National Center for Emerging and
Zoonotic Infectious Diseases, Centers for Disease Control and Prevention,
Anchorage Alaska. [email protected].

Abstract
Alaska Native people experienced the highest rates of acute and chronic
hepatitis B virus (HBV) infection, and hepatocellular carcinoma (HCC) in
the United States. We examine the effect of a universal newborn
immunization with hepatitis B vaccine and mass population screening
immunization program initiated in 1984 on rates of HBV and HCC in children
25 years later. During this time period, the population of Alaska Native
people grew from an estimated 75,000 to 130,000 persons. A surveillance
system to detect acute HBV infection in Alaska Native facilities was
established in 1981. Cases of HCC in children under 20 years of age were
identified using a National Cancer Institute (NCI) funded Cancer Registry
established in 1969 coupled with an active surveillance program of
screening persons with chronic HBV semiannually for alpha-fetoprotein since
1982. The incidence of acute symptomatic HBV infection in persons < 20
years of age fell from cases 19/100,000 in 1981-1982 to 0/100,000 in
1993-94, respectively. No cases of acute HBV have occurred in children
since 1992. The incidence of HCC in persons < 20 years decreased from
3/100,000 in 1984-1988 to zero in 1995-1999 and no cases have occurred
since 1999. The number of identified HBsAg-positive children < 20 years in
the Alaska Native Population declined from 657 in 1987 to two in 2008.
Universal newborn vaccination coupled with mass screening and immunization
of susceptible Alaska Native has eliminated HCC and acute symptomatic HBV
infection among Alaska Native children and this approach is the best way to
prevent HBV related disease in children.

(HEPATOLOGY 2011.).
Copyright © 2011 American Association for the Study of Liver Diseases.

PMID: 21618565 [PubMed - as supplied by publisher]



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StephenW

杂志。 2011年5月26日。分类号：10.1002/hep.24442。 [EPUB的提前打印]

肝癌和消除儿童急性B型肝炎
25年后乙肝新生儿和追赶的免疫方案。

麦克马洪北京，Bulkow LR的，单身的RJ，威廉姆斯J号，雪球男，霍曼ç，
帕金森欧塞尔。

来源
肝病和肝炎计划，阿拉斯加土著部落健康
财团，安克雷奇阿拉斯加北极调查计划，科
防备和新兴感染，新兴和国家中心
人畜共患传染病，疾病控制和预防中心
阿拉斯加州安克雷奇。 [email protected]。

摘要
阿拉斯加土著人经历了急性和慢性率最高
乙型肝炎病毒（HBV）感染，与肝细胞肝癌（HCC）的
美国。我们研究的一个普遍的新生儿的影响
接种乙肝疫苗和人口大规模筛查
免疫方案开始对乙型肝炎病毒和肝癌比率在1984年儿童
25年后。在这段时间内，外来人口的阿拉斯加
人们也从大约75,000至130,000人。监视
系统检测阿拉斯加土著设施急性HBV感染
成立于1981年。肝癌在儿童的案件在20岁以下
确定使用了国家癌症研究所（NCI）资助的癌症登记
成立于1969年加上一个积极监测方案
慢性乙肝病毒的人每半年检查的甲胎蛋白自
1982。有症状的急性HBV感染者的发病率“20
岁下降到案件100分之19，在1981-1982年至000 0 / 100，000
1993-94年度，分别为。急性乙肝病毒无病例发生在儿童
自1992年以来。人的肝癌发病率<20年下降
3 / 100，000在1995-1999年,1984 - 1988年为零，无案件发生
自1999年以来。查明的乙肝表面抗原阳性的儿童人数“20年
阿拉斯加外来人口下降，从1987年的两个657在2008年。
再加上通用新生儿接种质量检查和免疫接种
易感阿拉斯加本地人，他的肝癌，急性症状消除乙肝病毒
在阿拉斯加土著儿童感染这种方法是最好的办法
预防乙肝病毒在儿童有关的疾病。

（2011年肝病。）。
版权©为2011年美国肝病研究协会。