- 现金
- 62111 元
- 精华
- 26
- 帖子
- 30437
- 注册时间
- 2009-10-5
- 最后登录
- 2022-12-28
|
本帖最后由 风雨不动 于 2012-4-14 15:10 编辑
Hepatology. 2011 May 26. doi: 10.1002/hep.24442. [Epub ahead of print]
Elimination of hepatocellular carcinoma and acute hepatitis B in children
25 years after a hepatitis B newborn and catch-up immunization program.
McMahon BJ, Bulkow LR, Singleton RJ, Williams J, Snowball M, Homan C,
Parkinson AJ.
Source
Liver Disease and Hepatitis Program, Alaska Native Tribal Health
Consortium, Anchorage Alaska; Arctic Investigations Program, Division of
Preparedness and Emerging Infections, National Center for Emerging and
Zoonotic Infectious Diseases, Centers for Disease Control and Prevention,
Anchorage Alaska. [email protected].
Abstract
Alaska Native people experienced the highest rates of acute and chronic
hepatitis B virus (HBV) infection, and hepatocellular carcinoma (HCC) in
the United States. We examine the effect of a universal newborn
immunization with hepatitis B vaccine and mass population screening
immunization program initiated in 1984 on rates of HBV and HCC in children
25 years later. During this time period, the population of Alaska Native
people grew from an estimated 75,000 to 130,000 persons. A surveillance
system to detect acute HBV infection in Alaska Native facilities was
established in 1981. Cases of HCC in children under 20 years of age were
identified using a National Cancer Institute (NCI) funded Cancer Registry
established in 1969 coupled with an active surveillance program of
screening persons with chronic HBV semiannually for alpha-fetoprotein since
1982. The incidence of acute symptomatic HBV infection in persons < 20
years of age fell from cases 19/100,000 in 1981-1982 to 0/100,000 in
1993-94, respectively. No cases of acute HBV have occurred in children
since 1992. The incidence of HCC in persons < 20 years decreased from
3/100,000 in 1984-1988 to zero in 1995-1999 and no cases have occurred
since 1999. The number of identified HBsAg-positive children < 20 years in
the Alaska Native Population declined from 657 in 1987 to two in 2008.
Universal newborn vaccination coupled with mass screening and immunization
of susceptible Alaska Native has eliminated HCC and acute symptomatic HBV
infection among Alaska Native children and this approach is the best way to
prevent HBV related disease in children.
(HEPATOLOGY 2011.).
Copyright © 2011 American Association for the Study of Liver Diseases.
PMID: 21618565 [PubMed - as supplied by publisher]
(6.合.彩).足球.篮球...各类投注开户下注
第一投注.现金网:招代理年薪10万以上:6668.cc |
|