乙肝治疗：第6部-哪类人应该治疗？

三国杀

较容易，不是，不容易

StephenW

回复 三国杀 的帖子

请问
哪一篇文
？
http://www.medscape.com/viewarticle/554484_4
Favourable Outcome After Hepatitis B e Antigen Seroconversion                        Because most patients with cirrhosis or HCC were HBeAg negative and anti-HBe positive, it was argued that HBeAg seroconversion might implicate unfavourable outcome in chronic HBV infection.[39,40] This suggestion is not compatible with the results of a matched case control study showing that HBeAg-positive status increased the risk of HCC 3.6-fold when compared with HBeAg-negative HBsAg carriers.[41] This association has been confirmed by a recent prospective 8.5-year follow-up study involving 11 893 Taiwanese men, 30-65 years of age. In that study, the annual incidence of HCC was 1.2% for those who were HBsAg and HBeAg positive at enrolment, 0.3% for those who were HBsAg positive only, and 0.04% for those who were HBsAg negative. After adjusting for age, hepatitis C virus status, and use of cigarettes and alcohol, the relative risk for HCC was 9.6 (95% confidence interval, 6.0-15.2) among men who were positive for HBsAg alone and 60.2 (95% confidence interval, 35.5-102.1) for those who were positive for both HBsAg and HBeAg.[42] However, this study did not provide data comparing the incidence of HCC among carriers who underwent HBeAg seroconversion during follow-up vs those who remained HBeAg positive. In one cohort of 233 patients with HBeAg-positive chronic hepatitis B followed for a mean of 6.1 years without treatment, the annual incidence of cirrhosis and HCC was 1.8% and 0.4%, respectively, for 86 patients who had spontaneous HBeAg seroconversion and 3.7% and 1.6%, respectively (both P < 0.05), for those who remained HBeAg positive during follow-up.[43] Moreover, in one study on the natural course of chronic HBV infection after spontaneous HBeAg seroconversion in 283 patients reported from Taiwan, the overall annual incidence of cirrhosis and HCC development was estimated to be only 0.9% and 0.2%, respectively, during a mean follow-up of 9 years.[4] All these data implicate a favourable outcome of spontaneous HBeAg seroconversion in chronic HBV infection.

MP4

三国杀 发表于 2011-12-22 20:51
PS：我下文章不较容易，你们需要什么文章，可以帮忙下下来
但是，上这个网站有些困难 ...

有人能PDF翻译吗？

三国杀

回复 StephenW 的帖子

有两三天没上这个网了
没明白是什么意思

不好意思

三国杀

回复 MP4 的帖子

关于乙肝的临床型文章，我能够翻译
基础型的，或者，其他亚学科就比较困难了

MP4

三国杀 发表于 2011-12-25 12:29
回复 MP4 的帖子

关于乙肝的临床型文章，我能够翻译

http://good.gd/947523.htm
http://bioask.me/html/606.html
我想详细了解跟肠道的关系。

MP4

我开始讨厌骆淑芳
i don't like Anna Suk-Fong Lok
因为她的错误，导致全世界乙肝治疗指南的错误。
她应该正确理解朱嘉明教授的意思，接受Dieterich的意见。
希望她的免疫耐受临床试验能尽快出结果。
http://www.hbvhbv.com/forum/thread-1183871-1-1.html

StephenW

回复 MP4 的帖子

"因为她的错误，导致全世界乙肝治疗指南的错误。" - 指南是一个共识(consensus)文件。即使乐教授是领导成员，她的意见只是很多意见中的一个。
"她应该正确理解朱嘉明教授的意思，接受Dieterich的意见。" - 我不知道任何关于免疫耐受
“不治”的专家间的分歧。也许你可以向我们解释区别.

就个人而言，我相信在未来, 医生会治疗免疫耐受阶段的患者，当利大于弊时。