本帖最后由 StephenW 于 2011-4-9 14:17 编辑
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"治疗性乙肝疫苗并不是一个新概念，今天只不过是用一些新技术去攻克某些难关。但是它的理论似乎充满矛盾：你的免疫系统已经向病毒投降了，又怎么刺激它变聪明，去“反扑”这个病毒呢？"
"追随者们，很多连病毒最基本的免疫学和流行病学都没看过一眼，更没嗅过一篇正规杂志发表的"
请问你阅读过以下论文?刺激免疫系统是非常科学和合理."
1)http://www.hbvhbv.com/forum/thread-1015773-1-4.html
http://www.nature.com/nm/journal/v17/n3/full/nm0311-252.html
Finding mechanisms of viral resistance and new ways to tackle chronic hepatitis will help find a cure for this disease. In 'Bench to Bedside', Christopher Walker and Benoît Callendret highlight studies showing that overcoming immune exhaustion during chronic infection by blocking several inhibitory pathways of T cells may restore an adequate immune response. In 'Bedside to Bench', Lawrence Corey, Joshua Schiffer and John Scott discuss recent advances in antiviral therapy with protease inhibitors and the findings of a mathematical model that predicts possible single and double mutations prior to antiviral therapy.
2)http://www.hbvhbv.com/forum/thread-1003377-1-4.html
http://www.heraldsun.com.au/news/victoria/high-hopes-of-hiv-cure-by-injection-treatment-may-only-take-month/story-e6frf7kx-1225999810530
High hopes of HIV cure by injection, treatment may only take month
3)http://www.hbvhbv.com/forum/thread-1008144-1-5.html
[This is an excellent paper. Only the summary is posted here. Even though the trial was not successful, the paper is full of insights gained during the trial. I recommend the full paper to anyone interested in therapeutic vaccine for HBV. Stephen]
http://clinicaltrials.ploshubs.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014626
Partially Randomized, Non-Blinded Trial of DNA and MVA Therapeutic Vaccines Based on Hepatitis B Virus Surface Protein for Chronic HBV Infection
James S. Cavenaugh1,2,3¤, Dorka Awi1,4¤, Maimuna Mendy1,5¤, Adrian V. S. Hill2,6, Hilton Whittle1, Samuel J. McConkey1,2,7¤* 1 Medical Research Council Laboratories, Banjul, The Gambia, 2 Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom, 3David H. Smith Center for Vaccine Biology and Immunology, School ofMedicine and Dentistry, University of Rochester, Rochester, New York,United States of America, 4 Institute of Maternal and Child Health, University of Port Harcourt, Post Harcourt, Nigeria, 5 International Agency for Research on Cancer, Lyon, France, 6 The Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, 7 Department of International Health and Tropical Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
4)Review
Therapeutic vaccines and immune-based therapies for the treatment of chronic
hepatitis B: perspectives and challenges
Marie-Louise Miche, Qiang Deng, Maryline Mancini-Bourgine
PII: S0168-8278(11)00024-9
DOI: 10.1016/j.jhep.2010.12.031
Reference: JHEPAT 3692
To appear in: Journal of Hepatology
Received Date: 29 August 2010
Revised Date: 23 November 2010
Accepted Date: 20 December 2010
Please cite this article as: Miche, M-L., Deng, Q., Mancini-Bourgine, M., Therapeutic vaccines and immune-based
therapies for the treatment of chronic hepatitis B: perspectives and challenges, Journal of Hepatology (2011), doi:
10.1016/j.jhep.2010.12.031
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楼主: 八仙果
发表于 2011-4-9 09:53
