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本帖最后由 interdetect 于 2011-4-6 14:14 编辑
啥也不说了，看看恩替卡韦在动物上诱发的肿瘤吧。
Long-term oral carcinogenicity studies of entecavir in mice and rats were carried out . In mouse and rat studies, entecavir was positive for carcinogenic findings.
In mice, lung adenomas were increased in males and females. Lung carcinomas in both male and female mice were increased. Combined lung adenomas and carcinomas were increased in male mice and in female mice. Tumor development was preceded by pneumocyte proliferation in the lung, which was not observed in rats, dogs, or monkeys administered entecavir, supporting the conclusion that lung tumors in mice may be a species-specific event. Hepatocellular carcinomas were increased in males and combined liver adenomas and carcinomas were also increased. Vascular tumors in female mice (hemangiomas of ovaries and uterus and hemangiosarcomas of spleen) were increased. In rats, hepatocellular adenomas were increased in females; combined adenomas and carcinomas were also increased in females. Brain gliomas were induced in both males and females. Skin fibromas were induced in females.
尊重科学！远离主观臆断！
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楼主: interdetect
发表于 2011-4-6 13:56
