The change of the quantitative HBsAg level during the natural course of chronic

StephenW

<http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02516.x/abstract>

The change of the quantitative HBsAg level during the natural course of
chronic hepatitis B

Yu J. Kim, Hyun C. Cho, Moon S. Choi, Joon H. Lee, Kwang C. Koh, Byung C.
Yoo, Seung W. PaikArticle first published online: 22 MAR 2011

DOI: 10.1111/j.1478-3231.2011.02516.x
© 2011 John Wiley & Sons A/S
Issue

Liver International
Early View (Articles online in advance of print)

Abstract

Background: There is insufficient information about HBsAg levels and their
correlation with serum hepatitis B virus (HBV) DNA in chronic hepatitis B
(CHB).

Aims: We aimed to describe HBsAg levels during various phases of CHB and to
investigate the correlation with serum HBV DNA levels.

Methods: A total of 645 treatment-naïve Korean CHB patients were included
in this retrospective cross-sectional study. They were categorized into
immune tolerance (IT, n=56), HBeAg-positive hepatitis (EPH, n=150),
inactive carrier (IC, n=274) and HBeAg-negative hepatitis (ENH, n=165). The
baseline HBsAg and HBV DNA levels were measured.

Results: The mean HBsAg titres (log IU/ml) differed (P<0.001): IT 4.29, EPH
3.64, IC 2.05 and ENH 3.23. In 645 patients, HBsAg and HBV DNA showed a
significant correlation (r=0.693, P<0.001), and this was also observed in
the IT, EPH and IC groups (r=0.664, r=0.541, r=0.505, respectively, all
P<0.001), but not in the ENH group (r=0.093, P=0.321). Age had a negative
correlation with HBsAg (r=−0.451, P<0.001). The cirrhotic patients had a
significantly lower HBsAg level than the non-cirrhotic patients (2.41 ±
1.36 vs. 3.02 ± 1.21 log IU/ml, P<0.001).

Conclusions: The HBsAg level varied significantly in different phases of
CHB and was correlated with HBV DNA during the IT, EPH and IC phases. These
findings can provide additional information to understand the natural
course and pathogenesis of CHB.




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StephenW

在自然过程中的变化程度的定量乙肝表面抗原
慢性乙型肝炎

于J. Kim的，玄三祖，月亮学财，俊H ·李，许光三，丙三
柳，升瓦特PaikArticle首次发表时间：2011年3月22日

分类号：10.1111/j.1478-3231.2011.02516.x
©2011年约翰Wiley＆Sons出版A / S公司
发行

国际肝病
厄尔利维尤（第预先在网上打印）

摘要

背景：有关于乙肝表面抗原的水平和信息不足
血清乙肝病毒相关性（HBV）的DNA在慢性乙型肝炎
（乙肝）。

目标：我们的目的是描述在不同阶段的乙肝表面抗原水平，并
探讨血清乙肝病毒DNA水平的相关性。

方法：645治疗初治慢性乙型肝炎患者朝鲜共纳入
在这个回顾性横断面研究。他们被分为
免疫耐受（资讯科技组，n =56），e抗原阳性的肝炎（弗组，n =150），
非活动载体（集成电路，274例）和HBeAg阴性肝炎（ENH组，n =165）。该
基线HBsAg和HBV DNA水平的变化。

结果：平均乙肝表面抗原滴度（日志国际单位/毫升）相同（P“0.001）：它4.29，弗
3.64，2.05和ENH集成电路3.23。在645例，乙肝表面抗原和HBV DNA呈
显着的相关性（r=0.693，磷“0.001），这也是观察
资讯科技，弗和IC组相关（r=0.664，最终R =0.541，最终R =0.505，均
磷“0.001），但不是在ENH组（r=0.093，P值0.321）。年龄带来了负面
相关与HBsAg相关（r=-0.451，磷“0.001）。肝硬化患者有
显着降低乙肝表面抗原水平比非肝硬化患者（2.41±
1.36对比3.02±1.21日志国际单位/毫升，磷“0.001）。

结论：乙肝表面抗原水平差异显着的不同阶段
慢性乙型肝炎与HBV DNA，并在相关资讯，弗及IC阶段。这些
研究结果可提供额外的信息来了解自然
当然，与慢性乙型肝炎的发病机制。