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Enferm Infecc Microbiol Clin. 2020 Apr 22. pii: S0213-005X(20)30165-8. doi: 10.1016/j.eimc.2020.02.029. [Epub ahead of print]
Associations between hepatitis B infection and chronic kidney disease: 10-Year results from the U.S. National Inpatient Sample.
[Article in English, Spanish]
Geng XX1, Tian Z1, Liu Z2, Chen XM3, Xu KJ3.
Author information
1
Department of Career Development, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
2
Department of Career Development, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China. Electronic address: [email protected].
3
Department of Infectious Diseases, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
Abstract
INTRODUCTION:
Viral hepatitis infection is associated with negative impacts on renal function that may lead to nephropathy. We investigated associations between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) and/or end-stage renal disease (ESRD) in a large, representative sample from a nationwide U.S.
DATABASE:
METHODS:
This population-based, retrospective observational study extracted data from the U.S. Nationwide Inpatient Sample (NIS) database, including adults ≥18 years old admitted to U.S. hospitals between 2005 and 2014 with records of chronic HBV infection in medical history. The final analytic sample included 70,674 HBV-infected patients and 282,696 matched non-HBV controls. Study endpoints were prevalent CKD and ESRD. Associations between CKD/ESRD and HBV and patients' clinical characteristics were determined by logistic regression analysis.
RESULTS:
HBV infection was associated with slightly increased risk of prevalent CKD (OR: 1.06, 95% CI: 1.004-1.119) and an approximate 2-times risk of prevalent ESRD (OR: 1.98, 95% CI: 1.880-2.086). HBV infection in both genders was associated with slightly increased risk of CKD (males, OR: 1.09, 95% CI: 1.02-1.16; females, OR: 1.07, 95% CI: 0.98,1.17), and significantly associated with increased risk for CKD among non-diabetic patients (OR: 1.23, 95% CI: 1.15-1.32), white patients (OR: 1.14, 95% CI: 1.06-1.23) and Asian/Pacific Islanders (OR: 1.13, 95% CI: 0.98-1.30).
CONCLUSIONS:
Chronic HBV infection is associated with slightly increased risk for CKD and greater risk for ESRD in males and females, Whites and Asian/Pacific Islanders and non-diabetic patients.
Copyright © 2020 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
KEYWORDS:
Chronic kidney disease (CKD); End-stage renal disease (ESRD); Enfermedad renal crónica (ERC); Enfermedad renal terminal (ERT); Hepatitis B; Muestra nacional de pacientes hospitalizados (NIS); U.S. Nationwide Inpatient Sample (NIS)
PMID:
32334907
DOI:
10.1016/j.eimc.2020.02.029 |
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