HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(−) mothers

StephenW

<http://www.journalofclinicalvirology.com/article/PIIS1386653210004609/abstract?rss=yes>


HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(−) mothers

Vassiliki Papaevangeloua, Dimitrios Paraskevisb, Vassiliki Anastassiadouc,
Evaggelia Stratikid, Maria Machairaa, Irene Pitsoulia1, Catherine Haidab, Petros
Drakakisc, Klara Stamoulid, Aris Antsaklisc, Angelos Hatzakisb

Received 27 July 2010; received in revised form 10 November 2010; accepted 16
November 2010. published online 17 December 2010. Corrected Proof

Abstract

Background
Hepatitis B virus infection is an important public health problem worldwide and
eliminating mother-to-infant transmission is important to decrease the
prevalence of chronic HBV-infection. Although, immunoprophylaxis given at birth
largely prevents mother-to-infant transmission, perinatal HBV viremia has been
reported in HBsAg(−) newborns born mainly to HBeAg(+) women in endemic areas.

Objectives
To examine the incidence of perinatal HBV viremia in newborns of HBsAg(+)
predominantly HBeAg(−) mothers.

Study design
Peripheral blood was obtained at birth from 109 HBsAg(+) mothers and their
newborns before the administration of active–passive immunoprophylaxis.
Infants were prospectively followed and appropriately vaccinated.

Results
Although most (92.7%) of the HBsAg(+) mothers were HBeAg(−), 73.4% had
detectable HBV viremia. Neonatal viremia was detected in 3/8 (37.5%) and 24/101
(23.8%) newborns of HBeAg(+) and HBeAg(−) mothers, respectively (p=0.386).
However, HBV–DNA levels were significantly higher in newborns of HBeAg(+)
mothers (p=0.025). No child developed chronic HBV infection, but one child had
evidence of subclinical hepatitis.

Conclusions
Although the clinical significance of low viremia levels in almost one in four
newborns of HBsAg(+) mothers in a low endemicity area is unclear, it may enhance
our understanding of HBV mother-to-infant transmission.


a Second Department of Pediatrics, “P& A Kyriakou” Children's Hospital,
Medical School, Athens University, Goudi 11527, Athens, Greeceb Department of
Hygiene, Epidemiology and Medical Statistics, Medical School, Athens University,
Greecec First Department of Obstetrics and Gynecology, Alexandra Hospital,
Medical School, University of Athens, Athens, Greeced Neonatology Department,
Alexandra Hospital, Athens, Greece

Corresponding author. Tel.: +30 2107793000; fax: +30 2107774383.
1 Current address: First Department of Pediatrics, “A. Sophia” Children's
Hospital, Medical School, Athens University, Greece.

PII: S1386-6532(10)00460-9
doi:10.1016/j.jcv.2010.11.009
© 2010 Published by Elsevier Inc.

乙肝病毒表面抗原血症在（+）HBeAg的主要是白人新生儿（ - ）母亲

Vassiliki Papaevangeloua，迪米特里奥斯Paraskevisb，Vassiliki Anastassiadouc，
Evaggelia Stratikid，玛丽亚Machairaa，艾琳Pitsoulia1，凯瑟琳Haidab，佩特罗斯
Drakakisc克拉拉Stamoulid，阿里斯Antsaklisc，安耶洛斯Hatzakisb

收到2010年7月27日，在经修订的形式收到的2010年11月10日;接受16
2010年11月。网上公布2010年12月17日。更正的证明

摘要

背景
乙型肝炎病毒感染是一个重要的公共健康问题全球
消除母亲向婴儿传播重要的是要降低
患病的慢性HBV感染。虽然出生时免疫预防
主要是防止母亲向婴儿传播，母婴病毒血症已
报告中乙肝表面抗原（ - ）出生于HBeAg的主要流行地区（+）妇女新生儿。

目标
研究在新生儿乙肝表面抗原乙肝病毒血症的发病率围产期（+）
主要是e抗原（ - ）的母亲。

研究设计
外周血获得来自109个出生时乙肝表面抗原（+）母亲和她们的
新生儿前主被动免疫预防管理。
婴儿前瞻性随访并适当接种疫苗。

结果
虽然大多数的乙肝表面抗原（92.7％）（+）母亲为HBeAg（ - ），73.4％有
检测乙肝病毒血症。新生儿病毒血症检出3 / 8（37.5％）和101分之24
（23.8％）新生儿的HBeAg（+）和HBeAg（ - ）母亲，（P均= 0.386）。
但是，HBV - DNA水平显着提高新生儿的HBeAg（+）
母亲（p值= 0.025）。没有孩子发展为慢性乙肝病毒感染，但有一个孩子
亚临床肝炎的证据。

结论
虽然病毒血症水平低，几乎有四分之一的临床意义
新生儿乙肝表面抗原（+）在低度流行区的母亲目前还不清楚，它可能会增加
我们的理解乙肝病毒母亲向婴儿传播。


一儿科，“P和A Kyriakou”儿童医院二部，
医学院，雅典大学，沟底11527，雅典，Greeceb部
卫生，流行病学和医学统计学，医学学院，雅典大学，
Greecec妇产科，亚历山大医院第一部，
医学院，雅典，雅典，Greeced新生儿科大学
亚历山大医院，雅典，希腊

通讯作者。电话：。+30 210779.30万;传真：+30 2107774383。
1当前地址：首先儿科，“答索菲亚“儿童
医院，医学院，雅典大学希腊。

PII：S1386 - 6532（10）00460-9
分类号：10.1016/j.jcv.2010.11.009
© 2010爱思唯尔出版公司