E抗原阴性患者若HBVDNA高会增加纤维化风险

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Liver International ISSN 1478-3223

CLINICAL STUDIES

Increasing hepatitis B viral load is associatedwith riskof signi¢cant liver
¢brosis in HBeAg-negative but not HBeAg-positive chronic hepatitis B

Catherine M. N. Croagh1, Sally J. Bell1, John Slavin2, Yu X. G. Kong1, Robert Y Chen1, Stephen Locarnini3 and
Paul V Desmond1
1 Department of Gastroenterology, St Vincent’s Hospital, Fitzroy, Vic., Australia
2 Department of Pathology, St Vincent’s Hospital, Fitzroy, Vic., Australia
3 Victorian Infectious Diseases Reference Laboratory, North Melbourne, Vic., Australia

Conclusions
Our study of an Australian clinical cohort confirms that
CHB is associated with relatively high rates of significant
fibrosis, especially among ENHR patients, representing
the immune escape phase of disease or chronic HBeAgnegative
Hepatitis B. We confirm that there is a positive
correlation between high HBV DNA levels and the
presence of significant liver fibrosis in HBeAg-negative
disease but not in HBeAg-positive disease, and outline a
potential explanation for this based on the underlying
phase of disease. The factors predictive of significant
histological disease were age in HBeAg-positive patients,
and both HBV DNA and ALT in HBeAg-negative
patients.
The risk of liver inflammation and fibrosis in chronic
hepatitis B is the complex result of many interacting
factors and we argue that it is best considered in the
context of the traditional phase of disease model rather
than as a simple function of any single factor alone. In
particular, the HBV DNA level should not be relied on in
isolation to predict significant fibrosis/inflammation, but
rather needs to be interpreted as a measure of risk in the
context of other factors especially HBeAg status.



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yh0046

怎么没人把中心翻译下啊？我男友就是E抗原阴性的小三阳，DNA为，10^4。这个算高吗？怎么办啊？

zasxz

é抗原阴性患者若HBVDNA的高会增加纤维化风险
肝国际ISSN 1478-3223

临床研究

乙肝病毒载量增加是associatedwith riskof找出所有¢倾斜肝
e抗原阴性，但不是e抗原阳性慢性乙型肝炎¢ brosis

凯瑟琳百万Croagh1莎莉j的贝尔1，约翰Slavin2，星光Kong1于，罗伯特Ÿ国际眼科杂志和斯蒂芬Locarnini3
保罗V Desmond1
1消化内科，圣文森特医院的菲茨罗伊，维克。，澳大利亚
2病理科，圣文森医院，菲茨罗伊，维克。，澳大利亚
3维多利亚传染病参考实验室，北墨尔本，维克。，澳大利亚

结论
我们对澳大利亚的临床研究证实，队列
慢性乙肝是与相对高利率的显着
肝纤维化，特别是ENHR患者占，
为疾病或慢性HBeAgnegative免疫逃逸期
乙型肝炎我们确认，有一个积极的
乙肝病毒DNA的相关性高的水平和
存在重大肝纤维化的e抗原阴性
疾病，但不是在e抗原阳性的疾病，并提出
可能的解释这个基础上，基本
相疾病。重要的因素预测
病理病，e抗原阳性患者的年龄，
和乙肝病毒DNA和ALT均在HBeAg阴性
病人。
在慢性肝脏炎症的风险及纤维化
乙型肝炎是许多复杂的相互作用的结果
因素，我们认为它是最好的考虑
范围内的疾病模型，而传统的相
不是作为一个单独的任何一个因素的简单功能。在
尤其是，乙肝病毒DNA水平不应该依赖于
隔离预测显着纤维化/炎症，但
而需要被解释为一种风险衡量在
其他因素方面，尤其是HBeAg状态。