Prevalence of occult hepatitis B infection in a highly endemic area...

liver411

Gut. 2010 Jul 30. [Epub ahead of print]

Prevalence of occult hepatitis B infection in a highly endemic area for
chronic hepatitis B: a study of a large blood donor population.

Yuen MF, Lee CK, Wong DK, Fung J, Hung I, Hsu A, But DY, Cheung TK, Chan P,
Yuen JC, Fung FK, Seto WK, Lin CK, Lai CL.

The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Abstract
Background and aims The aim of the present study was to determine the
population prevalence of occult hepatitis B (OHB) infection and its clinical
profile in a highly endemic area of chronic hepatitis B virus disease. Methods
OHB was first identified by individual sample testing for hepatitis B surface
antigen (HBsAg) followed by nucleic acid testing (NAT) and vice versa for 3044
(cohort 1, stored sera from donation within 1 year) and 9990 (cohort 2,
prospective study) blood donors, respectively. OHB was confirmed meticulously
by >/=2 out of 3 tests with detectable hepatitis B virus (HBV) DNA using a
sensitive standardised assay. Detailed serology and viral load in the serum
and liver were studied. Results The prevalence of OHB was 0.13% (4/3044) and
0.11% (11/9967) for cohort 1 and 2, respectively. In cohort 2, 10 out of 11
OHB samples were positive for anti-HBc (hepatitis B core antigen) antibody
(all were immunoglobulin G). Seven had detectable anti-HBs. The serum HBV DNA
levels were extremely low (highest 14.1 IU/ml). Of the six donors who
underwent liver biopsies, all had normal liver biochemistry, extremely low
liver HBV DNA (highest 6.21 copies/cell) and nearly normal liver histology.
For those with viral sequence generation, none had the common HBsAg mutant
G145R. Conclusions The prevalence of OHB in a highly endemic area of chronic
HBV was very low, thus implying a low impact on transfusion services. To
implement universal screening, the high cost of NAT should be taken into
account. OHB blood donors had very low HBV replication, and normal liver
biochemistry and histology, conferring a favourable prognosis.

PMID: 20675695



(6.合.彩).足球.篮球...各类投注开户下注

第一投注.现金网:招代理年薪10万以上:6668.cc