“中国重大发现 肝癌基因曝光”？

liver411

明报    2010-08-02

中国医学界有重大发现，由来自解放军军事医学科学院、复旦大学等机构的百多名科学家，用了两年时间终于找出在人体染色体内容易导致肝癌的基因，这项重大原创研究成果将有助科学家进一步就预防肝癌、治疗及研製特效药方面提供理论依据。

助预防治疗肝癌

中新社消息指出，这项突破性成果由解放军军事医学科学院的蛋白质组学国家重点实验室所发现，科学院院长贺福初及研究员周钢桥在昨日的记者会上表示，他们与南京医科大学、中国医学科学院肿瘤研究所、复旦大学、中山大学肿瘤医院等10多个机构的100多位科学家，在内地5个肝癌高发地区收集4500多名肝癌病例和对照个桉，经过两年多研究，在人体第1号染色体的一个特殊位置，发现了一个由多个基因组成的区域，而该区域正是导致肝癌的「罪魁祸首」。这项成果，已于昨日在国际学术期刊《自然－遗传学》（Nature Genetics）网站上公布。

据医院管理局癌病资料统计中心数据显示，肝癌是香港第三大癌症杀手，死亡率高踞第三；而中国每年新病例多达30万，佔全球肝癌新病例的半数以上。

[ 本帖最后由 liver411 于 2010-8-3 17:26 编辑 ]



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威廉梦想

我觉的以后发这样的帖子都需要考证一下,当然,我决没有怀疑411老师的想法

liver411

Nature Genetics | Letter
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers

       *      Hongxing Zhang,    *      Yun Zhai,    *      Zhibin Hu,    *      Chen Wu,    *      Ji Qian,    *      Weihua Jia,
    *      Fuchao Ma,    *      Wenfeng Huang,    *      Lixia Yu,    *      Wei Yue,    *      Zhifu Wang,    *      Peiyao Li,
    *      Yang Zhang,    *      Renxiang Liang,    *      Zhongliang Wei,    *      Ying Cui,    *      Weimin Xie,    *      Mi Cai,   
*      Xinsen Yu,    *      Yunfei Yuan,    *      Xia Xia,    *      Xiumei Zhang,    *      Hao Yang,    *      Wei Qiu, ]   *
      Jingmin Yang,    *      Feng Gong,    *      Minshan Chen,    *      Hongbing Shen,    *      Dongxin Lin,    *      Yi-Xin Zeng,    *      Fuchu He    *      & Gangqiao Zhou    * et al.
    * Affiliations    * Contributions    * Corresponding authors
Journal name:    Nature Genetics
Year published:    (2010)
DOI:    doi:10.1038/ng.638

Received    12 February 2010
Accepted    08 July 2010
Published online    01 August 2010

To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in 355 chronic HBV carriers with HCC and 360 chronic HBV carriers without HCC, all of Chinese ancestry. We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios. Across the six studies, the association with rs17401966 was highly statistically significant (joint odds ratio = 0.61, P = 1.7 × 10−18). In addition to KIF1B, the association region tagged two other plausible causative genes, UBE4B and PGD. Our findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy.

View full text

   1.
      These authors contributed equally to this work.
          * Zhibin Hu,
          * Chen Wu,
          * Ji Qian &
          * Weihua Jia

Affiliations

   1.
      State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
          * Hongxing Zhang,
          * Yun Zhai,
          * Lixia Yu,
          * Wei Yue,
          * Zhifu Wang,
          * Peiyao Li,
          * Yang Zhang,
          * Mi Cai,
          * Xia Xia,
          * Xiumei Zhang,
          * Hao Yang,
          * Wei Qiu,
          * Feng Gong,
          * Fuchu He &
          * Gangqiao Zhou
   2.
      Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
          * Zhibin Hu &
          * Hongbing Shen
   3.
      Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
          * Chen Wu &
          * Dongxin Lin
   4.
      MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
          * Ji Qian &
          * Jingmin Yang
   5.
      State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, China.
          * Weihua Jia,
          * Yunfei Yuan &
          * Yi-Xin Zeng
   6.
      Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
          * Weihua Jia &
          * Yi-Xin Zeng
   7.
      Cancer Institute of Guangxi, Nanning, Guangxi, China.
          * Fuchao Ma,
          * Wenfeng Huang,
          * Ying Cui &
          * Weimin Xie
   8.
      Liver Cancer Institute at Fusui County, Guangxi, China.
          * Renxiang Liang &
          * Zhongliang Wei
   9.
      Disease Prevention and Control Center at Haimen County, Jiangsu, China.
          * Xinsen Yu
  10.
      Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
          * Minshan Chen
  11.
      Institute of Biomedical Sciences, Fudan University, Shanghai, China.
          * Fuchu He

Contributions

G.Z. and F.H. were the overall GWAS study principal investigators who conceived the study and obtained financial support. F.H., G.Z. and H.Z. designed the study. Y.C., W.X., R.L., Z.W., F.M. and W.H. were responsible for recruitment of Guangxi subjects, phenotype collection and biological sample collection and preparation. W.J., Y.Y., M.C. and Y.-X.Z. were responsible for recruitment of Guangdong subjects, phenotype collection and biological sample collection and preparation. Z.H., H.S. and X.Y. were responsible for recruitment of Jiangsu subjects, phenotype collection and biological sample collection and preparation. J.Y. and J.Q. were responsible for recruitment of Shanghai subjects, phenotype collection and biological sample collection and preparation. C.W. and D.L. were responsible for recruitment of Beijing subjects, phenotype collection and biological sample collection and preparation. Y.Z., L.Y., P.L., Z.W., F.M., W.H., W.Y., M.C., X.Z., W.Q., H.Y. and H.Z. performed genotyping in the replication stage. X.X. helped to manage genotype data. F.G., Y.Z. and F.M. conducted functional experiments. G.Z. and H.Z. conducted sample selection and data management, performed statistical analyses, interpreted results and wrote the manuscript.
Competing financial interests

The authors declare no competing financial interests.
Corresponding authors

Correspondence to:

    * Gangqiao Zhou ([email protected]) or
    * Fuchu He ([email protected])

Supplementary information
  

PDF FILE: 补充文献，图表



http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.638.html

自由港

通过其重大发现，防癌的具体措施是？

liver411

正确的解读应该是：

Nature Genetics：发现人体内导致肝癌的易感基因 而不是 新华社 说的“重大发现”

有助于以后的研究，其它目前不能做什么。

wbd555

学习了，呵呵

天华

基础研究，想要应用还需要走很长的路

九头猫

有希望，漫漫等待……

hunterpt

好久没跟贴了　这个最近　最让人解闷的一则　消息了　

确实是不错的新闻

MP4

好，非常好。