細胞激素濃度 可測B肝病情

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中文：

20100724 14:51:48        
（中央社記者陳清芳台北24日電）台大醫院和台北榮民總醫院今天發表聯合研究指出，血液中2種有關免疫反應的細胞激素，可用來預測B型肝炎病情，有助於未來量身訂製慢性B肝的治療方式。

根據台大醫院小兒部醫師吳嘉峰、教授張美惠、台北榮總兒童胃腸科主任吳子聰從17年來追蹤病例中發現，介白質10與12血清濃度較高的慢性B肝患者，出現自發性B肝e抗原抗體血清轉換的時間，平均會提早10年。

吳嘉峰與吳子聰解釋，e抗原代表B肝病毒的活動，當e抗原陽性時，顯示B肝病毒持續複製活動，當e抗原消失轉陰時，換成e抗體出現，顯示B肝病毒受到人體免疫力的抑制。

吳嘉峰說，現行的慢性B肝治療準則，即將「e抗原陽轉陰」列為治療的目標之一，因為e抗原也可做為日後預測B肝病人是否罹患肝癌的重要標記。

介白質10和12與免疫相關的細胞激素，台大和台北榮總研究團隊從病患肝臟組織檢查、肝癌細胞的培養中，證實這2種細胞激素及其下游的免疫調節分子，對B肝病毒感染與肝癌病程，扮演一定的角色。

現有多種抗病毒藥物可治療慢性B肝，但臨床發現，治療1年後只有2到3成病患達到減少病毒量、e抗原陽轉陰等治療目標，大多數病人的療程超過1年，少數超過5年。台大和台北榮總的研究認為，病人的介白質10和12的基因表現，影響到藥效發揮。

這項研究已在今年元月發表於肝膽胃腸醫學排名第1的Gastroenterology期刊上，預測未來可檢測細胞激素濃度，發展出客製化療程，根據病情調整藥物。990724




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英文：

Taiwan researchers find way to predict hepatitis B virus activity
2010/07/24 21:13:02


Taipei, July 24 (CNA) Taiwanese researchers have found a way to "customize" treatments for individual hepatitis B patients by predicting the activity of the virus, according to the head of the research team Saturday.

The study, which analyzed cases of hepatitis B virus (HBV) infections reported in the past 17 years, found two intercellular mediators in the immune system that can "predict" HBV activity, said Wu Jia-feng, a pediatrician at National Taiwan University Hospital.

In chronic HB patients, the team found, there is a higher concentration of the mediators -- known as interleukin-10 and interleukin-12 -- which trigger the HB antigen (HBeAg) earlier than in those with a lower concentration of the mediators.

Wu explained that when a patient tests positive for HBeAg it means the virus is reproducing, while a negative result means the immune system has suppressed the hepatitis B virus.

The goal of HB treatments has been to "turn the HBeAg negative," Wu said.

Existing anti-viral drugs have not been very effective in the treatment of HB patients, as only 20 percent to 30 percent have shown signs of improvement after taking the drugs for one year, Wu said.

The intercellular mediators could be a factor in the ineffectiveness of the drugs, he added.

The study was published in the U.S.-based Gastroenterology journal in January. (By Chen Ching-fang and Elizabeth Hsu) enditem /pc

走遍四方

介白質===白介素？？？？？？？