Hepatitis B virus-induced liver fibrosis and cirrhosis:

liver411

<http://www3.interscience.wiley.c ... =1&SRETRY=0>

Journal of Digestive Diseases
Volume 11 Issue 4, Pages 215 - 223
Published Online: 26 May 2010
Journal compilation © 2010 Chinese Medical Association Shanghai Branch,
Chinese Society of Gastroenterology and Blackwell Publishing Asia Pty Ltd

Hepatitis B virus-induced liver fibrosis and cirrhosis: The value of liver and
spleen volumetry with multi-detector spiral computed tomography

Wei Xia LI,* Xiang Tian ZHAO,* Wei Min CHAI,* Nai Yi ZHU,* Lian Jun DU,* Wei
HUANG,* Hua Wei LING,* Ke Min CHEN* & Qing XIE �€

*Department of Radiology and �€  Department of Infectious Diseases, Ruijin
Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence to Ke Min CHEN, Department of Radiology, Ruijin Hospital,
Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Email: [email protected]

Copyright Journal compilation © 2010 Chinese Medical Association Shanghai
Branch, Chinese Society of Gastroenterology and Blackwell Publishing Asia Pty
Ltd.

ABSTRACT

OBJECTIVE: To study the correlation of liver and spleen volume with the degree
of liver fibrosis and cirrhosis induced by hepatitis B virus infection.
METHODS: 128 participants who had undergone liver and spleen volumetry were
enrolled. The control group consisted of 41 participants who were potential
living liver donors. The liver fibrosis group consisted of 63 histologically
proved liver fibrosis patients who were further divided into two subgroups: 44
patients with slight liver fibrosis, and 19 patients with advanced liver
fibrosis. The liver cirrhosis group consisted of 24 patients. The following
parameters were determined by multi-detector spiral computed tomography (MSCT)
examination: total liver volume (TLV), right liver lobe volume (RV), left
lateral liver segment volume (LLV), left medial liver segment volume (LMV),
caudate lobe volume (CV), and spleen volume (SV). The ratios of CV to TLV
(C/T), RV to TLV (R/T), LLV to TLV (LL/T), LMV to TLV (LM/T), and SV to TLV
(S/T) were calculated.
RESULTS: TLV, RV, LMV tended to decrease and SV, C/T, S/T tended to increase
gradually with the increased degree of fibrosis. C/T ≥ 3.34% and S/T ≥
47.36% were identified as the cut-off values of fibrosis ≥F3 (advanced liver
fibrosis) and cirrhosis, respectively. Their sensitivities were 68.4% and
87.5% and their specificities were 59.1% and 89.5%, respectively.
CONCLUSION: Variations in liver and spleen volume correlated with the degree
of liver fibrosis and cirrhosis and could be used in the non-invasive
follow-up of the development of liver fibrosis.

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DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1751-2980.2010.00441



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