A longitudinal study on the natural history of HBsAg

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Hepatology
Early View (Articles online in advance of print)
Published Online: 11 Jun 2010
Copyright © 2010 American Association for the Study of Liver Diseases


Viral Hepatitis
A longitudinal study on the natural history of serum hepatitis B surface
antigen changes in chronic hepatitis B

Henry Lik-Yuen Chan *, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Chi-Hang
Tse, Hoi-Yun Chan, Joseph Jao-Yao Sung
Department of Medicine and Therapeutics and Institute of Digestive Disease,
The Chinese University of Hong Kong, Hong Kong SAR, China

email: Henry Lik-Yuen Chan ([email protected])

*Correspondence to Henry Lik-Yuen Chan, Department of Medicine and
Therapeutics, 9/F Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin,
Hong Kong SAR, China

Potential conflict of interest: Henry L. Y. Chan is an advisory board member
of Hoffmann La-Roche, Abbott Diagnostics, Novartis Pharmaceutical, and
Bristol-Myers Squibb.
fax: 852-26373852

Funded by:
Direct Grant for Research, The Chinese University of Hong Kong; Grant Number:
2041344

Abstract

Serum hepatitis B surface antigen (HBsAg) quantification has been suggested to
reflect the concentration of covalently closed circular DNA in the liver. We
aimed to investigate the HBsAg levels at different stages of chronic hepatitis
B and the changes in HBsAg level during the natural progression of disease.
One hundred seventeen untreated patients with chronic hepatitis B were studied
with longitudinal follow-up for 99 ± 16 months. HBsAg quantification was
performed at the first visit, the last visit, and three visits at each
quartile during the follow-up. At the first visit, HBsAg level was higher
among patients who were hepatitis B e antigen (HBeAg)-positive (N = 49) than
those who were HBeAg-negative (N = 68) (4.01 ± 0.91 log IU/mL versus 2.73 ±
1.25 log IU/mL, P < 0.001). HBsAg level was persistently high at approximately
5 log IU/mL among patients in the immune tolerance phase (N = 7). The HBsAg
levels among patients with HBeAg-positive active disease (N = 25) or sustained
HBeAg seroconversion (N = 17) were comparable at approximately 3-4 log IU/mL.
The HBsAg levels among patients who were HBeAg-negative tended to be higher
among patients with active (N = 46) than those with inactive disease (N = 22).
The median HBsAg levels decreased in HBeAg-negative patients with active and
inactive disease by 0.041 log IU/mL/year and 0.043 log IU/mL/year,
respectively. Twenty-two (17%) patients had HBsAg reduction>1 log IU/mL at the
last visit; most of them showed reduced hepatitis B virus DNA, and eight had
HBsAg loss. Conclusion: HBsAg remained stable in HBeAg-positive patients and
tended to reduce slowly in HBeAg-negative patients. Reduction of HBsAg for>1
log IU/mL could reflect improved immune control. (HEPATOLOGY 2010)
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Received: 18 January 2010; Accepted: 3 June 2010
Digital Object Identifier (DOI)
10.1002/hep.23803



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hatecccdna

Conclusion: HBsAg remained stable in HBeAg-positive patients and
tended to reduce slowly in HBeAg-negative patients. Reduction of HBsAg for>1
log IU/mL could reflect improved immune control.

thanks

齐欢畅2

原帖由 hatecccdna 于 2010-7-24 16:41 发表
Conclusion: HBsAg remained stable in HBeAg-positive patients and
tended to reduce slowly in HBeAg-negative patients. Reduction of HBsAg for>1
log IU/mL could reflect improved immune control.

thanks ...

zasxz

so must make eAg neg and eAb pos in order to reduce sAg by 1log IU/ml

MP4

香港中文大学威尔士亲王医院陈力元教授

yh0046

e抗原阴性者表面抗原会缓慢下降（阳性者保持稳定）？这么说随着时间的延长，小三肯定会转阴啊？

yh0046

e抗原阴性者表面抗原会缓慢下降（阳性者保持稳定）？这么说随着时间的延长，小三肯定会转阴啊？