Trends in the Indication and Method of Liver Biopsy for Hepatitis B and C

liver411

<http://www.springerlink.com/content/58n36863h1m4h643/>

Trends in the Indication and Method of Liver Biopsy for Hepatitis B and C
Journal Digestive Diseases and Sciences
Publisher Springer Netherlands
ISSN 0163-2116 (Print) 1573-2568 (Online)
Category Original Article
DOI 10.1007/s10620-010-1337-8
Subject Collection Medicine
SpringerLink Date Friday, July 16, 2010


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Original Article
Trends in the Indication and Method of Liver Biopsy for Hepatitis B and C

Michael J. Lipp1 , Lionel S. D’Souza2 , David J. Clain1 , Henry C.
Bodenheimer Jr.1  and Albert D. Min1

(1)  Division of Digestive Diseases, Beth Israel Medical Center, First Avenue
at 16th Street, 17-BH, New York, NY 10003, USA
(2)  Department of Internal Medicine, Beth Israel Medical Center, New York,
NY, USA

Received: 27 March 2010  Accepted: 21 June 2010  Published online: 15 July 2010

Abstract

Background and Aims
Liver biopsy plays a crucial role in assessing inflammation and fibrosis in
chronic hepatitis. The aim of this study was to compare the indications and
methods for performing a liver biopsy over a 15-year period when there were
evolving strategies and increasing therapeutic options for the treatment for
chronic hepatitis B (HBV) and C (HCV).
Methods
We reviewed all percutaneous liver biopsies performed at our center from 1992
to 2007 using a pathology database. Variables collected included indication
for biopsy, use of real-time ultrasound (US) guidance, and complications
associated with the biopsy.
Results
A total of 3,572 total liver biopsies were performed between 1992 and 2007
with a gradual increase in annual liver biopsies from 1992 to 2001. After a
peak in 2003, there was a gradual decline in liver biopsies performed. The
number of liver biopsies done for HCV peaked in 2003, followed by an annual
decrease until 2006, while the number of annual biopsies done for HBV
increased during the same period. In addition, the proportion of liver
biopsies performed with real-time US-guidance increased steadily since 1997.
Conclusions
Changes in liver biopsy trends at our center may be related to several
factors, including the evolving treatment strategies for HCV and HBV.
Percutaneous liver biopsies were increasingly performed using real-time
US-guidance over the past decade, a change that may reflect practice patterns
around the country.



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