Experiement HBV drug pipeline report

StephenW

I apologise for not posting this in Chinese, I hope some of you will be kind enough to translate this into Chinese if they think it is worthwhile.

I forwarded the following message from Lei Chou, someone who knows a lot about HBV treatment:

  ”We¹ve just published our annual experimental drug pipeline report, my
  chapter on HBV starts on page 70. Sorry the news is not more exciting. You
  can download the report here:
  <http://treatmentactiongroup.org/publication.aspx?id=3798>


  Lei Chou
  Hepatitis/HIV Project Coordinator
  Treatment Action Group
  611 Broadway, Suite 308
  New York, NY 10012
  Mobile: +1 917.355.3684
  Tel: +1 212.253.7922 x. 215
  Fax: +1 212.253.7923
  [email protected]
  Www.treatmentactiongroup.org

You will not find REP9AC and Alinia mentioned in the report. I asked Lei the question:

In your research, did you come across REP 9AC by Replicor  and Alinia from Romark?  REP 9AC had a very small clinical trial involving only  6 patients, but all were reported cured. The Canadian company behind it seems to have no money for any further work. Alinia is FDA approved for another medical condition but has been reported to be effective against HBV and HCV. A few people (in Medhelp) are trying the drug for their HBV condition. The Chief medical officer of Romark is Dr Emmet Keeffer, a well known HBV researcher. Again, there is no ongoing trial involving Alinia. Can you shed any light on why no big pharma seems to interested in these two drugs or  any other?

This is the reply:

I tried to dig up some more information on REP 9AC, to no
avail. Since it's in such an early phase, combined with the small trial done[reported]
in China, I didn't feel there are sufficient data to include it here. I may
be proven wrong, but in general when something sounds too good yet is
lacking financing, I wait to hear more. I contacted Dr. Keeffer two years
ago, who said they were moving forward with Alinia in the states, but have
not heard about any trials to date. I believe they are focusing on the hep C
side. There are other compounds out there that are in similar fates.

I think the difficulty right now is that the two first line drugs on the
market are setting very high bars on efficacy and resistance barrier. For a
new drug to get developed, they'll have to show potential for shorter
duration of treatment, or eradication, not just another "me too" drug. I'm
hopeful that some of the therapeutic vaccines might eventually pan out, but
it's going to be a few years before we can get some definitive answers.


I believe it is time for all of us to organize to urge the Government to fund and initiate a national 5-year project to find a cure for HBV. Chinese scientists, together with colleagues from Taiwan, Hong Kong, Korea, Singapore, Japan, and others can find a cure with the help of governments. If not, we can all donate to start our own research institute.



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走遍四方

two first line drugs ==ETV and TDF?   thanks stephe

StephenW

Yes, Entecavir + Tenofovir

lzwp

强烈关注REP9AC，同时关注战友们正在试用的硝唑尼特，但愿都有上佳表现！

布隆方丹

原帖由 lzwp 于 2010-7-22 15:17 发表
强烈关注REP9AC，同时关注战友们正在试用的硝唑尼特，但愿都有上佳表现！

说的具体点

batibaby

Translate them simply，please understand and forgive the imprecise contents.
简单的翻译了一下，不确切的地方请谅解：
---------------------------------------
I apologise for not posting this in Chinese, I hope some of you will be kind enough to translate this into Chinese if they think it is worthwhile.
非常抱歉没能用中文发布此贴，我希望有人认为有价值的话能翻译成中文。

I forwarded the following message from Lei Chou, someone who knows a lot about HBV treatment:
我从Lei Chou出转发的下面的消息，lei chou 是一个对HBV治疗非常了解的人。
  ”We¹ve just published our annual experimental drug pipeline report, my
  chapter on HBV starts on page 70. Sorry the news is not more exciting. You
  can download the report here:
  http://treatmentactiongroup.org/publication.aspx?id=3798
“我们已经发布了我们的年度药物试验报告，我的和HBV有关的章节从第70页开始，非常抱歉此消息不是很令人振奋。你们可以在此链接出下载药物试验报告。”


  Lei Chou
  Hepatitis/HIV Project Coordinator
  Treatment Action Group
  611 Broadway, Suite 308
  New York, NY 10012
  Mobile: +1 917.355.3684
  Tel: +1 212.253.7922 x. 215
  Fax: +1 212.253.7923
  [email protected]
  Www.treatmentactiongroup.org

You will not find REP9AC and Alinia mentioned in the report. I asked Lei the question:
你们在lei chou提到的报告中找不到REP9AC和Alinia，我想Lei咨询了此问题：
In your research, did you come across REP 9AC by Replicor  and Alinia from Romark?  REP 9AC had a very small clinical trial involving only  6 patients, but all were reported cured. The Canadian company behind it seems to have no money for any further work. Alinia is FDA approved for another medical condition but has been reported to be effective against HBV and HCV. A few people (in Medhelp) are trying the drug for their HBV condition. The Chief medical officer of Romark is Dr Emmet Keeffer, a well known HBV researcher. Again, there is no ongoing trial involving Alinia. Can you shed any light on why no big pharma seems to interested in these two drugs or  any other?
在你的研究中，你们碰到过（使用过）Replicor的REP9AC和Romark的Alinia没有？Rep9ac仅经历过包含6个病人的小规模的临床试验，但是据报道所有的病人都被治愈了。背后的加拿大的公司看起没有更多的资金来继续以后的工作。Alinia是有FDA批准的另一个对HBV和HCV有效的药物。MedHelp上的一些人正在使用此药物进行HBV治疗。Romark的CMO是Emmet Keeffer博士，他or她是一个非常有名的HBV研究人员。此外，没有其他的关于Alinia的更进一步的消息。您能不能阐述一下为什么没有大的医药公司对这两种或其他的药物感兴趣？

This is the reply:
这是来自于Lei Chou的回复：
I tried to dig up some more information on REP 9AC, to no
avail. Since it's in such an early phase, combined with the small trial done[reported]
in China, I didn't feel there are sufficient data to include it here. I may
be proven wrong, but in general when something sounds too good yet is
lacking financing, I wait to hear more. I contacted Dr. Keeffer two years
ago, who said they were moving forward with Alinia in the states, but have
not heard about any trials to date. I believe they are focusing on the hep C
side. There are other compounds out there that are in similar fates.
我试图搜集过更多的关于REP9AC的信息，但是没有找到。既然REP9AC的实验还处于一个比较初级的阶段（据报道只完成了很少的临床试验），我认为在中国关于REP9AC还没有更多的数据。我的想法可能会被证明是错的，但是一般来讲听上去疗效好的药物会缺少商业价值，我在等待更多的信息。我在两年前联系过Keeffer博士，他说他们正在美国进行Alinia相关的工作，但是到今天也没有听说任何的临床试验。我相信他们（I believe they are focusing on the hep C side）。There are other compounds out there that are in similar fates.


I think the difficulty right now is that the two first line drugs on the
market are setting very high bars on efficacy and resistance barrier. For a
new drug to get developed, they'll have to show potential for shorter
duration of treatment, or eradication, not just another "me too" drug. I'm
hopeful that some of the therapeutic vaccines might eventually pan out, but
it's going to be a few years before we can get some definitive answers.

我想现在的困难在于这两种药物要作为一线药物推广到市场上会有很好的疗效？(set very high bars on efficacy)和阻碍？（resistance barrier）。对于一个新开发的新药，他们应该表现出更小的（或者说是没有）耐药性的潜力，而不是于其他的已有的药物具备没有差异的疗效。我希望治疗性疫苗最后能成功，但是可能要有好几年才能得到最后的答案。


I believe it is time for all of us to organize to urge the Government to fund and initiate a national 5-year project to find a cure for HBV. Chinese scientists, together with colleagues from Taiwan, Hong Kong, Korea, Singapore, Japan, and others can find a cure with the help of governments. If not, we can all donate to start our own research institute.
我相信现在到了我们组织起来推动政府来资助或者创建一个5年规划来寻找治疗HBV的治疗方法。中国大陆的科学家连同台湾、香港、韩国、新加坡、日本和其他的一些同事就能够在政府的帮助下寻找治疗方法。否者，我们就只能自己捐款来成立属于我们自己的研究机构。

StephenW

Many thanks, excellent translation!

zasxz

it is a good will, but our govt seems not interested in developing such good drug for our hbvers. they are only caring about gdp and export.

StephenW

That is what I used to believe, but in a recent article in Nature, it described that China do spend a lot of money on medical and drug research. It is just not focused on HBV. We need to encourage the government to spend more and exclusively on HBV drug research.