Risk assessment for the development of hepatocellular carcinoma

StephenW

J Hepatol. 2010 Apr 4. [Epub ahead of print]

Risk assessment for the development of hepatocellular carcinoma: According to
on-treatment viral response during long-term lamivudine therapy in hepatitis B
virus-related liver disease.

Eun JR, Lee HJ, Kim TN, Lee KS.
Division of Hepatology, Department of Internal Medicine, Yeungnam University
College of Medicine, Daegu, Republic of Korea.

Abstract

BACKGROUND & AIMS: To assess the risk for the development of hepatocellular
carcinoma (HCC) according to the underlying liver status and on-treatment
viral response during long-term lamivudine therapy in patients with hepatitis
B virus-related liver disease.

PATIENTS AND METHODS: Between March 1997 and February 2005, a total of 872
patients were treated with lamivudine for more than oneyear. Between 1983 and
1998, a total of 699 patients were enrolled as historical controls.

RESULTS: For patients with compensated cirrhosis, HCC occurred in 4.9% (5/103)
of cases with sustained viral suppression (persistently <141,500copies/ml),
11.8% (20/170) in cases with viral breakthrough, and 19.4% (7/36) in cases
with a suboptimal response (persistently 141,500copies/ml): the mean follow-up
was 5.1+/-2.7, 5.4+/-2.3, and 3.7+/-1.8years, respectively. For the control
group, HCC developed in 25.0% (37/148) of the cases during a mean follow-up of
6.1+/-4.3years. Thus, the annual incidence of HCC was 0.95%, 2.18%, 5.26%, and
4.10% in patients with sustained viral suppression, viral breakthrough,
suboptimal response, and the control group, respectively. The cumulative
incidence of HCC in patients with sustained viral suppression was
significantly lower than in patients with a suboptimal response and the
controls (p=0.002 and p=0.005, respectively). In patients without cirrhosis
and with decompensated cirrhosis, the preventive effects of lamivudine on the
development of HCC were not observed (p=0.446 and p=0.123, respectively).

CONCLUSION: Lamivudine therapy reduced the incidence of HCC in patients with
compensated cirrhosis when the viral suppression was sustained.

Copyright © 2010 European Association for the Study of the Liver. Published
by Elsevier B.V. All rights reserved.

PMID: 20471129 [PubMed - as supplied by publisher]



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jsmscym

建议版主，今后发英文的必需带翻译全文，不然的话删除。

肝胆相照009

原帖由 jsmscym 于 2010-5-28 20:37 发表
建议版主，今后发英文的必需带翻译全文，不然的话删除。

何必呢？应该感谢LZ资源共享才是

富贵数字

我感觉楼主发那么多英文的帖子  既然懂英文 那就顺便翻译下重点分享比较好，
这里很多都不懂的, 在线翻译的都不准 ,

hatecccdna

楼主只发了摘要，没有全文。

如果是有意义的文章，把摘要翻译一下也好。

统计了一下，这样的帖子发了60多篇。如果只是大量简单copy英文摘要，没有任何实际意义。

走遍四方

还是要感谢的。