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本帖最后由 风雨不动 于 2012-4-14 16:11 编辑
Imiquimod[咪喹莫特]软膏作为第一个供患者自行使用的外用尖锐湿疣治疗(HPV)免疫调节药物，攻克了尖锐湿疣复发的难题，开创治疗尖锐湿疣的里程碑。
最近荷兰 （Netherlands），Leiden 大学医疗中心先用 Imiquimod[咪喹莫特] 涂抹在接种乙肝疫苗无反应者的接种部位，之后再在预先用药膏涂抹过的部位来接种5mug的乙肝疫苗。分别在 0，1，6 个月都涂抹药膏后分期接种疫苗。结果， 实验显示，Imiquimod [咪喹莫特]虽然不能激发体液免疫，在不考虑涂抹药膏情况下，此前没有答应的接种者在涂抹药膏后产生了抗体...。
或许，不能得到答应的乙肝疫苗接种者不妨可以试一下Imiquimod[咪喹莫特]药膏。
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疫苗杂志：
Vaccine. 2010 Apr 27. [Epub ahead of print]
Intradermal hepatitis B vaccination in non-responders after topical
application of imiquimod (Aldara((R))).
Roukens AH, Vossen AC, Boland GJ, Verduyn W, van Dissel JT, Visser LG.
Department of Infectious Diseases, Leiden University Medical Center, The
Netherlands.
Abstract
Trial registration: NTR1043
<http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1043>. BACKGROUND:
Five to ten percent of immunocompetent persons fail to develop a protective
immune response to hepatitis B vaccination, and are defined non-responders
(NR). We investigated the immune response to intradermal hepatitis B
vaccination after pre-treatment of the skin with the TLR7 agonist imiquimod.
METHODS: Twenty-one non-responders (anti-HBs <10IU/l after at least 6
intramuscular hepatitis B vaccinations) were randomly assigned to the control
group (N=11) or the experimental group (N=10). Participants in both groups
received 3 intradermal (ID) vaccinations with 5mug HBsAg (0.125mL) at 0, 1 and
6 months. In the experimental group, the dermal site of injection was
pre-treated with 250mg imiquimod ointment. Anti-HBs antibodies were determined
at 0, 1, 2, 6 and 7 months. RESULTS: In both study groups, 70% of the
participants developed a protective immune response (anti-HBs>/=10IU/l), after
the 3rd intradermal vaccination. CONCLUSION: The application of imiquimod on
the skin prior to intradermal vaccination did not enhance the humoral response
to hepatitis B vaccine. However, irrespective of imiquimod application, 70% of
the NR who had not responded to 6 previous intramuscular vaccinations,
developed a protective immune response with high affinity antibodies after 3
ID hepatitis B vaccinations with 5mug HBsAg. Copyright © 2010. Published by
Elsevier Ltd.
PMID: 20433806 [PubMed - as supplied by publisher]
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发表于 2010-5-13 11:44
