Features and clinical implications of hepatitis B virus genotypes

StephenW

<http://www.journalofclinicalviro ... 40/abstract?rss=yes>

JOURNAL OF CLINICAL VIROLOGY

Features and clinical implications of hepatitis B virus genotypes and
mutations in basal core promoter/precore region in 507 Chinese patients with
acute and chronic hepatitis B

Yan Liua1, Yanwei Zhonga1, Zhengsheng Zoub, Zhihui Xua, Baosen Lib, Xiaoqiang
Rena, Siyu Baia, Lin Wanga, Xiaodong Lia, Jiuzeng Daia, Yao Wanga, Panyong
Maoa, Dongping Xua

Received 21 August 2009; received in revised form 17 October 2009; accepted 18
December 2009. published online 18 January 2010.
Corrected Proof


Abstract
Background
The association of hepatitis B virus (HBV) genotypes and basal core promoter
(BCP) and precore (PC) mutations with the clinical characteristics is
increasingly recognized.
Objective
To investigate virologic features and clinical implications of HBV genotypes,
BCP and PC mutations between large-size patients with acute hepatitis B (AHB)
and chronic hepatitis B (CHB).
Study design
One hundred and eighty-two AHB patients and 325 CHB patients were
investigated. HBV genotypes and BCP/PC mutations were determined by direct
sequencing. Mutations at 10 interested sites of the BCP/PC region were
compared between the two groups of patients.
Results
AHB patients had a significantly higher ratio of genotype B to C than CHB
patients (37.4–62.6% vs. 16.6–83.4%, P<0.001). The prevalence of BCP/PC
wild-type virus was 60.4% in AHB patients in contrast to 28.9% in CHB
patients. Significantly lower prevalence of A1762T, G1764A, G1896A, and G1899A
but higher prevalence of T1758C was found in AHB patients. Interestingly,
T1758C and A1762T/G1764A appeared mutual restraint. Genotype B virus had lower
BCP mutation frequency and similar PC mutation frequency compared to genotype
C virus. AHB patients with BCP/PC mutant virus had higher viral load, whereas
CHB patients with BCP/PC mutant virus had lower viral load and elevated
alanine aminotransferase, in comparison with those with the wild-type virus.
Conclusion
Patients with genotype B virus, BCP/PC wild-type virus or T1758C mutant virus
were more susceptible to develop AHB, whereas high prevalence of the BCP/PC
mutations was associated with CHB development.

a Viral Hepatitis Research Laboratory, Institute of Infectious Diseases,
Beijing 302 Hospital, Beijing 100039, China
b The 4th Department of Infectious Diseases, Beijing 302 Hospital, Beijing
100039, China
Corresponding author. Tel.: +86 10 6387 9286; fax: +86 10 6387 9286.

1 These authors contributed equally to this work.

PII: S1386-6532(09)00604-0
doi:10.1016/j.jcv.2009.12.013

© 2009 Elsevier B.V. All rights reserved.

走遍四方

victory:

[ 本帖最后由 走遍四方 于 2010-2-10 14:46 编辑 ]

StephenW

I am not a doctor, so I am unable to reply to your question. May I suggest you contact the Corresponding author. Tel.: +86 10 6387 9286; fax: +86 10 6387 928
They may be able to help.

走遍四方

THANKS YOU