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发表于 2001-11-24 21:04
Hepatitis A, B and C
-new hepatitis therapies
Zadaxin
Infergen (interferon alphacon-1)
synthetic, bioengineered type-1 interferon
custom amino acid sequences by concensus design
combines characteristics of several different interferon alphas
chronic hepatitis C infection therapy
4 million adults in USA
8.9 million in Europe
170 million worldwide
HCV infection leading cause of need for liver transplantation
Intron® A (interferon alpha-2b)
partnership with Schering-Plough
targets hepatitis B and C
$1.1 billion in sales, 1999
Rebetol (Ribavirin)
targets hepatitis C
first drug approved against hepatitis C
Rebetron (combination of ribavirin and interferon alpha-2b)
approved by FDA
partnership of Schering-Plough and ICN Pharmaceuticals
$1.1 billion in sales, 1999
Vaccine for Hepatitis B
partnership with SmithKline-Beecham/Merck
Ostavir Human Anti-Hepatitis B Antibody (OST 577)
chronic hepatitis B infection
combination with lamivudine
VP50406
inhibits RNA replication of hepatitis C virus (HCV)
not interferon based
interferon based treatments are available
side effects
only 10-40% effective
Recombivax
hepatitis B vaccine
partnership with Chiron (royalties)
.
Adefovir dipivoxil
once-a-day oral dosage
reverse transcriptase inhibitor
nucleotide analogue chain terminator
LY466700 (Heptazyme)
ribozyme against conserved genomic sequences of HCV
hepatitis C virus is an RNA virus (no DNA)
genes are encoded in the RNA
ribozyme digests RNA in hepatitis C virus
cuts all known types of HCV RNA
virus cannot replicate and infect
patent protection of ribozymes specific to HCV RNA
partnership with Eli Lilly
VX-497
inhibitor of inosine monophosphate dehydrogenase (IMPDH)
antiviral effects
anti-inflammatory
may be more beneficial in combination with interferon therapy
HCV Protease Inhibitor
direct viral enzyme target
3D structure discovered by Vertex in 1996
HCV NS3 protease
key role in viral reproduction
partnership with Eli Lilly
HCV Helicase Inhibitor
direct viral enzyme target
3D structure discovered by Vertex in 1998
HCV NS3 helicase
required for HCV reproduction
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