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发表于 2001-11-30 22:32
Types of HBV Genomes
The following is a list of the major types of HBV genomes found in the human population:
1993: Genetic relatedness of hepatitis B viral strains of diverse
geographical origin and natural variations in the primary
structure of the surface antigen.
1995: Subtypes, genotypes and molecular epidemiology of the
hepatitis B virus as reflected by sequence variability of the S-
gene.
1998: Antigenic diversity of hepatitis B virus strains of genotype F in
Amerindians and other population groups from Venezuela.
6 Genotypes (A,B,C,D,E,F) [PMID: 8336122]
Group A - Orig - N. Europe - Sub-Saharan Africa
Group B - Confined to - Eastern Asia (China)
Group C - Far East (Japan)
Group D - Mediterranean - Near, Mid East, South Asia
Group E - W. Sub-Saharan Africa, south to Angola
Group F - New World - Brazil, N. + S. America
121 Strains Exist as Quasispecies
There are four serotypes which are based on subtypes of the hepatitis B surface antigen (HBsAg). These are defined by two mutually exclusive determinant pairs d/y and w/r with a common determinant 'a'. These subtypes are adw, ayw, adr, and ayr.
Four genomic groups of HBV were later referred as genotypes designated with A-D. Sequencing of the S-gene of HBV is the molecular basis for the assessment of the serological variations of HBsAg within the major four subtypes. Two new genotypes of HBV are designated with E and F. The F genotype diverges from other HBV genomes sequenced by 14%. So far, it is the most divergent HBV genome. Worldwide molecular epidemiology of HBV is based on the variability of the S-gene. The E and F strains appear to originate from aboriginal populations of Africa in the New World.
[ 此消息由 liver411 在 2001-11-30.08:47:51 编辑过 ] |
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